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Antibiotic targeting of wolbachia endosymbiotic bacteria as a new approach to the treatment of filarial infection and disease

Ziel

Wolbachia are symbiotic endobacteria in filarial nematodes that have recently emerged as targets for an improved chemotherapy of filariasis by tetracycline antibiotics, with the potential to close the gaps left open in current mass treatment programs. The purposes of this project are i) to obtain the optimal regimen with anti-Wolbachia antibiotics leading to Wolbachia depletion and sterilization or killing of adult worms in human filariasis (lymphatic filariasis, loiasis and onchocerciasis); ii) to analyse the role of Wolbachia in inflammatory processes which lead to disease manifestations (acute episodes of lymphangitis); iii) to investigate the role of Wolbachia release by microfilaricidal therapy in the induction of drug side effects. In their combination, the studies will allow to assess the role of Wolbachia in pathogenesis and as targets for the long-needed for sustained interruption of transmission.

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CSC - Cost-sharing contracts

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UNIVERSITY OF BONN MEDICAL CENTER
EU-Beitrag
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Adresse
Sigmund-Freud-Strasse 25
53105 BONN
Deutschland

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Letzte Aktualisierung: 12 April 2005

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Permalink: https://cordis.europa.eu/project/id/ICA4-CT-2002-10051/de

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