Obiettivo Wolbachia are symbiotic endobacteria in filarial nematodes that have recently emerged as targets for an improved chemotherapy of filariasis by tetracycline antibiotics, with the potential to close the gaps left open in current mass treatment programs. The purposes of this project are i) to obtain the optimal regimen with anti-Wolbachia antibiotics leading to Wolbachia depletion and sterilization or killing of adult worms in human filariasis (lymphatic filariasis, loiasis and onchocerciasis); ii) to analyse the role of Wolbachia in inflammatory processes which lead to disease manifestations (acute episodes of lymphangitis); iii) to investigate the role of Wolbachia release by microfilaricidal therapy in the induction of drug side effects. In their combination, the studies will allow to assess the role of Wolbachia in pathogenesis and as targets for the long-needed for sustained interruption of transmission. Campo scientifico natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics Programma(i) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF BONN MEDICAL CENTER Contributo UE Nessun dato Indirizzo Sigmund-Freud-Strasse 25 53105 BONN Germania Mostra sulla mappa Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto LEIDEN UNIVERSITY Paesi Bassi Contributo UE Nessun dato Indirizzo Albinusdreef 2 2300 RC LEIDEN Mostra sulla mappa Costo totale Nessun dato LIVERPOOL SCHOOL OF TROPICAL MEDICINE Regno Unito Contributo UE Nessun dato Indirizzo Pembroke Place L3 5QA LIVERPOOL Mostra sulla mappa Costo totale Nessun dato RESEARCH FOUNDATION IN TROPICAL DISEASES AND ENVIRONMENT Camerun Contributo UE Nessun dato Indirizzo Molyko BUEA Mostra sulla mappa Costo totale Nessun dato TROPICAL MEDICAL RESEARCH STATION KUMBA Camerun Contributo UE Nessun dato Indirizzo 40 KUMBA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF INDONESIA Indonesia Contributo UE Nessun dato Indirizzo 6,Salemba Raya 6 10430 JAKARTA Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF SCIENCE AND TECHNOLOGY, KUMASI Ghana Contributo UE Nessun dato Indirizzo University Post Office 30 KUMASI Mostra sulla mappa Costo totale Nessun dato
