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Prevalance characterisation & prevention of latent autoimmune diabetes in adults (lada) in europe (action lada)

Objective

A substantial proportion of patients with non-insulin requiring diabetes progress to insulin therapy. Many cases, despite being adults, have immune and genetic features of autoimmune type 1 diabetes. Such adult autoimmune non-insulin requiring diabetic patients probably comprise the majority of cases of autoimmune diabetes in Europe and their condition is described as latent autoimmune diabetes of adults (LADA). This proposal aims:
1 ) to define the prevalence of LADA across Europe by testing non-insulin requiring diabetes patients for antibodies to glutamic acid decarboxylase;
2) to characterise LADA in terms of genetic, immune and metabolic features, and
3) to prevent or delay progression to insulin dependence in LADA using a immune modulation therapy with a heat shock protein altered peptide (Diapep 277). The double-blind randomised prevention trial will determine in a group of recent onset LADA patients whether therapy with Diapep277 can modify the natural history of the disease. Such therapy, if successful in reducing progression to insulin dependence, could be used to prevent autoimmune type 1 diabetes in children.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

N/A

Participants (12)

DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT E.V.
Germany
Address
Auf'm Hennekekamp 65
40225 Duesseldorf
FONDAZIONE DIABETE ENDOCRINOLOGIA METABOLISMO
Italy
Address
Largo Ettore Marchiafava 1
00161 Roma
INSTITUT FUER STOFFWECHSEIFORSCHUNG
Austria
Address
C/o Krankenanstalt Rudolfstiftung, Juchgasse 25
1030 Wien
NATIONAL PUBLIC HEALTH INSTITUTE
Finland
Address
166,Mannerheimintie 166
00300 Helsinki
ODENSE UNIVERSITY HOSPITAL
Denmark
Address
Sdr. Boulevard 29
5000 Odense
PEPTOR LTD
Israel
Address
Kyriat Weizmann Industrial Park, Building 16
76326 Rehovot
QUINTILES LTD
United Kingdom
Address
Innovex House, Fieldhouse Lane
SL7 1HY Marlow,bucks
RESEARCH INSTITUTE OF THE HOSPITAL DE SANTA CREU I SANT PAU
Spain
Address
Avinguda Sant Antoni Maria Claret 167
08025 Barcelona
THE ROYAL GROUP OF HOSPITALS AND DENTAL HOSPITAL HEALTH AND SOCIAL SERVICES TRUST
United Kingdom
Address
Grosvenor Road
BT12 6BA Belfast
UNIVERSITAETSKLINIKUM DUESSELDORF
Germany
Address
Moorenstrasse 5
40225 Duesseldorf
UNIVERSITE CLAUDE BERNARD LYON 1
France
Address
8 Rue Guillaume Paradin
69372 Lyon
UNIVERSITY OF WALES SWANSEA
United Kingdom
Address
Singleton Park
Swansea