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New approaches to treatment and control of Lassa fever and Yellow fever in West Africa

Objective

From survivors of LF or YF, combinatorial phage-display antibody libraries will be constructed and neutralizing antibodies will be selected. Recombinant antibodies will be used for studying the molecular mechanisms of virus neutralization and will be engineered for immunotherapy. Mastomys natalensis, the principal rodent vector of Lassa virus, appears to be a morphologically indistinguishable complex of subspecies in West Africa. We will develop cytogenetic and molecular techniques to differentiate these subspecies and correlate them with their vector capacity for Lassa virus. A better understanding of the vector biology of Mastomys may lead to new ecological approaches for the Control of LF. To improve YF surveillance in Africa, new PCR strategies will be developed to detect all recently described five genotypes of YF in pooled mosquitoes.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

PHILIPPS UNIVERSITY MARBURG
Address
Robert Kochstrasse 17
35037 Marburg
Germany

Participants (4)

INSTITUT PASTEUR
France
Address
Avenue Tony Garnier 21
69365 Lyon
INSTITUT PASTEUR DE COTE D'IVOIRE
Côte d’Ivoire
Address

01 Abidjan
MUSEUM NATIONAL D'HISTOIRE NATURELLE
France
Address
Rue Buffon 55
75005 Paris
UNIVERSITE DONKA
Guinea
Address
Chu Donka
Conakry