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Environmental factors that affect the development of prion diseases

Objective

The work proposed here brings together top EU geo- and biochemists focusing on determining the environmental factors that affect the development of prion diseases such as scrapie, bovine spongiform encephalitis (BSE), chronic wasting disease (CWD) and Creutzfeld-Jacobs disease (CJD). First the geographical distribution of manganese and copper in soils will be investigated as risk factors. This will be undertaken due to the fact that prion diseases often are found in clusters and the fact that it now has been established that the normal metal for prion protein is copper but if that metal is replaced with manganese the structure of the prion protein is altered. The role of organophosphate pesticides will also be investigated because it has been suggested that copper is cornplexed with organophosphate, preventing copper absorption.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

UNIVERSITY OF BRISTOL
Address
Queens Road, Wills Memorial Building
BS8 1RJ Bristol, Clifton
United Kingdom

Participants (7)

ALPINE INSTITUTE OF ENVIRONMENTAL DYNAMICS
France
Address
Rue Du Puy, 108
38660 Lumbin
FREIE UNIVERSITAET BERLIN
Germany
Address
Kaiserswertherstrasse 16-18
Berlin
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Prince Consort Road
SW7 2B London
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
Address
Piazza Dell'universita, 1
06123 Perugia
UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
France
Address
Avenue Centrale 621
38041 Grenoble
UNIVERSITY OF BATH
United Kingdom
Address
Claverton Down
BA2 7AY Bath
UNIVERSITY OF ICELAND
Iceland
Address
3,Suourgotu
107 Reykjavik