CORDIS
EU research results

CORDIS

English EN
The genetic and neurobiological basis of x-linked mental retardation (euro-mrx).

The genetic and neurobiological basis of x-linked mental retardation (euro-mrx).

Objective

With a prevalence of about 2%, mental retardation (MR) poses an important medical and socio-economic problem. The European MRX Consortium has been instrumental in characterizing families with non-specific X-linked MR (MRX) and cloning most of the MRX genes, with two objectives:
(1) increasing the possibilities for genetic counselling for MR (X) and
(2) elucidation of the neurobiological mechanisms underlying MR, to create a basis for therapeutic intervention. Using neuronal tissue cultures and genetically modified mice we will study the biological mechanisms which link MRX gene defects to deficient cognitive functioning in humans. In addition, cloning of additional MRX genes will be accelerated using highly innovative approaches. These studies will greatly enhance our understanding of the cellular basis of cognition.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

STICHTING KATHOLIEKE UNIVERSITEIT

Address

10,Geert Grooteplein 10
6500 Hb Nijmegen

Netherlands

Administrative Contact

Jos WERMER (Dr)

Participants (7)

Sort alphabetically

Expand all

CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS

Cyprus

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

KAROL MARCINKOWSKI UNIVERSITY OF MEDICAL SCIENCES - ACADEMY OF MEDICINE

Poland

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

Germany

ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCE

Netherlands

Project information

Grant agreement ID: QLG3-CT-2002-01810

  • Start date

    1 January 2003

  • End date

    31 December 2005

Funded under:

FP5-LIFE QUALITY

  • Overall budget:

    € 2 346 197

  • EU contribution

    € 1 699 999

Coordinated by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands