Cel Thrombotic occlusion of atherosclerotic coron arteries is the common cause of acute myocardial infarction, and platelet-dependent thrombotic diseases are the first cause of death in the Westem Society. The general objective of this joint research project is to establish a highly competitive open- wall research and training infrastructure in thrombosis, based on the complementary expertise of 7 leading European laboratories, who have combined their efforts in a multidisciplinary approach to(a) investigate the molecular mechanisms underlying blood-platelet interactions with the vasculature,(b ) develop cell-type and receptor specific antagonists that will prevent uncontrolled platelet adhesion events leading to cardiovascular diseases, and(c) use state-of -the-art real time technologies to assess the efficiency of these antagonists in flowing blood conditions in vitro and in vivo.At the scientific level, our objectives are(1) to define the three-dimensional structural requirements necessary for the interaction of major prothrombogenic matrix proteins such as collagen and vWF with their respective receptors (integrins alpha2Beta1 and alphaIIBeta3, GPIb), using recombinant proteins for cocrystallisation experiments and atomic force microscopy analysis;(2) to design and synthesize small triple helical collagen-derived peptides as collagen mimetics;(3) to identify new receptor antagonists by screening parasite extracts and parasite-derived cDNA expression libraries, peptide and antibody display libraries;(4) to use platelet proteomics and MALDI- TOF technology to identify new intracellular integrin receptor ligands as potential targets for anti-thrombotic drug development, and(5) to generate new prothrombotic mice models through transgenic knock-in technology. A major objective of this network is to offer young predoctoral and postdoctoral EU-scientists high quality training in a broad spectrum of state-of-the-art technologies applied to cardio Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineangiologyvascular diseasesnatural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicinecardiologycardiovascular diseases Program(-y) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Temat(-y) Data not available Zaproszenie do składania wniosków Data not available System finansowania NET - Research network contracts Koordynator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Wkład UE Brak danych Adres Rue du Général Leclerc 84 94276 LE KREMLIM BICETRE Francja Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (6) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko CENTRE DE RECHERCHE PUBLIC DE LA SANTE Luksemburg Wkład UE Brak danych Adres 162 A,Avenue de la Faiencerie 162 A, Centre Universitair 1511 LUXEMBOURG Zobacz na mapie Koszt całkowity Brak danych KATHOLIEKE UNIVERSITEIT LEUVEN Belgia Wkład UE Brak danych Adres 53,E. Sabbelaan 53 Universitaire Campus 8500 KORTRIJK Zobacz na mapie Koszt całkowity Brak danych ROYAL COLLEGE OF SURGEONS IN IRELAND Irlandia Wkład UE Brak danych Adres Saint Stephen's Green 123 DUBLIN Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY MEDICAL CENTRE UTRECHT Niderlandy Wkład UE Brak danych Adres Heidelberglaan 100 3584CX UTRECHT Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF DEBRECEN Węgry Wkład UE Brak danych Adres Nagyerdei krt. 98 4012 DEBRECEN Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF NOTTINGHAM Zjednoczone Królestwo Wkład UE Brak danych Adres University Park NG7 2RD NOTTINGHAM Zobacz na mapie Koszt całkowity Brak danych