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Undergraduated student

Obiettivo

One of the most exciting frontiers of macromolecular science in the new millennium lies probably in widening the scope and sharpening the specific merits of polymer therapeutics. This implies the development of new generations of bioactive polymers. Bioactive polymers are synthetic polymers capable either of improving the mode of action of other active substances, as in the case of targetable polymer drug carriers, or of exerting a biological activity of their own, as in the case of membrane. active polymers with a potential as transfection promoters. They are in general functional polymers; that is, polymers endowed with reactive chemical functions, as exemplified by the well-known Ringsdorf model of polyrner-drug conjugate (Fig. 1). Poly( amidoamine )s (pAAs ) are synthetic teramino polymers obtained by stepwise polyaddition of primary or secondary aliphatic amines to bis-acrylamides . The polymerisation reaction takes place in solvents carrying mobile protons, such as water or alcohols, at room temperatures and without added catalysts. High monomer concentrations and relatively low reaction temperatures the best results Aprotic solvents, even ifhighly polar, are unsuitable as reaction media yielding only low molecular weight products. The ammo groups react only if present as free base (Fig. 2). P AAs are by themselves highly functional polymers. However, further functionalisation of P AAs may be useful for special purposes. In many cases, the introduction of additional functions in p AAs as side substituents can be simply achieved starting from the corresponding functional monomers. For instance, hydroxy; ter -amino; allyl-, amido- and ether groups if present in the monomers do not interfere mth the polymerisation process ( Fig- 3). Very important are the amphoteric PAAs, that are PAAs carrying acidic functions as side substituents, in most cases carboxyl groups. They are obtained by using either carboxylated bis-acry!amides or aminoa

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FRANCHINI JACOPO
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Indirizzo
Via Matteotti 45/100
20020 ARESE
Italia

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