Cel The DNA Damage Response (DDR) protects the genome from cytotoxic and mutagenic effects of chemicals and radiation in the environment. Genetic defects in DDR lead to genome instability and predispose individuals to diseases like cancer. DDR is a rapid, dynamic and integrated response to genome insult which co- ordinates cell cycle progression, DNA replication and DNA repair. Our understanding of DDR has been based largely on the use of specific approaches in specific model organisms: e.g. genetics in yeast, biochemistry in frogs, cytology in mammalian cells, etc. The participating teams are experts with these model organisms who are committed to expanding their repertoire of technical and conceptual approaches to studying DDR. Our objectives are:- To characterize mechanisms of genome surveillance in response to DNA damage and DNA replication stress by studying several key components (PI(3)- related kinases and associated subunits, Sgs1 helicasef PCNA and RF-C-related DDR components).- To examine the role of novel Components of the DNA damage signal transduction pathway.- To characterize the downstream effects of DDR on DNA replication, chromatin structure and ubiquit in mediated proteolysis. In each case, a multidisciplinary approach will involve the study of processes and proteins in different organisms using different technical strategies. This unique European collaboration will lead to new advances and contribute to an integrated view of DDR in eukaryotic cells. Dziedzina nauki natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologycytologynatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP5-HUMAN POTENTIAL - Programme for research, technological development and demonstration on "Improving the human research potential and the socio-economic knowledge base" (1998-2002) Temat(-y) 1.4.1.-1.1. - Research Training Networks Zaproszenie do składania wniosków Data not available System finansowania NET - Research network contracts Koordynator CANCER RESEARCH UK Wkład UE Brak danych Adres Clare Hall Laboratories, Blanche Lane EN6 3LD POTTERS BAR Zjednoczone Królestwo Zobacz na mapie Koszt całkowity Brak danych Uczestnicy (7) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko BEN GURION UNIVERSITY OF THE NEGEV Izrael Wkład UE Brak danych Adres 84105 BEER SHEVA Zobacz na mapie Koszt całkowity Brak danych CANCER RESEARCH UK Zjednoczone Królestwo Wkład UE Brak danych Adres Blanche Lane, Clare hall Laboratories EN6 3LD SOUTH MIMMS Zobacz na mapie Koszt całkowity Brak danych ERASMUS UNIVERSITEIT ROTTERDAM Niderlandy Wkład UE Brak danych Adres Dr. Molewaterplein 50 3000 DR ROTTERDAM Zobacz na mapie Koszt całkowity Brak danych INSTITUT CURIE Francja Wkład UE Brak danych Adres Rue d' Ulm 26 75248 PARIS Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF GENEVA Szwajcaria Wkład UE Brak danych Adres 30,Quai Ernest Ausermet 30 1211 GENEVE Zobacz na mapie Koszt całkowity Brak danych UNIVERSITY OF SUSSEX Zjednoczone Królestwo Wkład UE Brak danych Adres Falmer BN1 9RR BRIGHTON / FALMER Zobacz na mapie Koszt całkowity Brak danych UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA Włochy Wkład UE Brak danych Adres Piazza della Scienza 2 20126 MILANO Zobacz na mapie Koszt całkowity Brak danych
