CORDIS
EU research results

CORDIS

English EN
Linkage between genome stability and checkpoint control

Linkage between genome stability and checkpoint control

Objective

The preservation of genome stability is an essential process in every living organism. DNA can be damaged by a variety of agents and in a number of ways, often with deleterious consequences to cell survival. To prevent such consequences, DNA damage triggers a multitude of responses in eukaryotic cells, including DNA damage signaling and repair, and delay of cell cycle progression until repair is complete. This latter response is referred to as the "DNA damage checkpoint". If this checkpoint fails for any reason, genome instability can result. In higher eukaryotes, this can lead to cancer, accelerated ageing and/or certain neurodegenerative disease states. In this application, a set of complementary genetic and biochemical approaches are proposed for the study of the linkage between genome stability maintenance and checkpoint control. The nine laboratories in the proposed network will use biological systems that will allow the efficient integration of these complementary approaches. The main objectives to be addressed are briefly summarized as follows: - To understand the molecular function of DNA helicases involved in the preservation of genomic stability in yeast and humans. These helicases include S. cerevisiae Sgs 1 p, Srs2p, Dna2p, Mph1p, and the human XPB, XPD, BLM and WRN proteins - To establish how the activity of DNA repair and recombination proteins is controlled by checkpoint proteins The achievement of these objectives will allow the network to define the functions and interactions of the different components of the DNA replication, repair and recombination machineries and to understand the regulatory circuits connecting these processes with checkpoint control. This information is a prerequisite to obtaining a complete insight into cellular growth control and how these controls are modified during tumorigenesis and other disease states.

Coordinator

University of Cambridge

Address

Tennis Court Road
Cb2 1qr Cambridge

United Kingdom

Administrative Contact

Jones SIMON

Participants (8)

Sort alphabetically

Expand all

CANCER RESEARCH UK

United Kingdom

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

ERASMUS UNIVERSITEIT ROTTERDAM

Netherlands

GEORG-AUGUST-UNIVERSITY GOETTINGEN

Germany

HOSPTIAL UNIVERSITARIO DE CANARIAS (HUC)

Spain

IFOM FONDAZIONE FIRC DI ONCOLOGIA MOLECULARE

Italy

UNIVERSITY OF AARHUS

Denmark

UNIVERSITY OF ZURICH

Switzerland

Project information

Grant agreement ID: HPRN-CT-2002-00240

  • Start date

    1 December 2002

  • End date

    30 November 2005

Funded under:

FP5-HUMAN POTENTIAL

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Coordinated by:

University of Cambridge

United Kingdom