Objective The biological processes mediating bystander responses are incompletely understood despite the relevance of this phenomenon to radiation protection and radiation therapy. The present proposal contributes to the elucidation of the mechanisms underlying bystander effects by evaluating intercellular communication as a determinant of the response, and DNA double strand breaks as initiating lesions. Using biological model systems with conditional induction of intercellular communication and diverse experimental approaches, some of which are developed and tested here, we aim to investigate the induction kinetics of by stander effects in cultured cells and evaluate their contribution to the response of tumors growing in nude mice to ionizing radiation. The results should allow the definition of targets for pharmacological intervention to protect humans from the adverse effects of ionizing radiation. Fields of science natural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physics Programme(s) FP5-EAECTP C - Research and training programme (Euratom) in the field of nuclear energy (1998 to 2002) Topic(s) 2.1.3.-1.1. - Risk estimates for exposures at low dose and low dose rate Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITY OF ESSEN EU contribution No data Address Hufelandstrasse 55 45147 ESSEN Germany See on map Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all BUNDESREPUBLIK DEUTSCHLAND Germany EU contribution No data Address Budensallee 100 38116 BRAUNSCHWEIG See on map Total cost No data FACULTY OF MEDICINE/UNIVERSITY HOSPITAL GOETTINGEN Germany EU contribution No data Address Robert-Koch-Strasse 40 37075 GOETTINGEN See on map Total cost No data NATIONAL CENTRE FOR SCIENTIFIC RESEARCH 'DEMOKRITOS' Greece EU contribution No data Address Terma Patriarchou Grigoriou 15310 ATHENS See on map Total cost No data UNIVERSITY OF ST ANDREWS United Kingdom EU contribution No data Address Queen's Terrace Bute Medical Buildings KY16 9TS St Andrews, Fife See on map Total cost No data