Skip to main content

Evaluation of the facilitation of umbilical cord blood transplant engraftment using ex vivo haematopoietic progenitor/stem cell expansion.

Objective

Umbilical cord blood cells collected at birth are increasingly used as a source of stem cells for transplants in patients with malignant and non-malignant diseases. Previous EUROCORD programs have identified prognostic factors for predicting the outcome. Delay of engraftment is the major problem particularly in adults. Using clinical data from EUROCORD Registry, we have identified several factors associated with engraftment including the cell dose and the role of HLA incompatibilities. In this new proposal, we plan to coordinate research on methods to improve clinical results of CBT assaying different strategies aiming to shorten engraftment time and to increase its probability by means of ex-vivo expansion of haematopoietic progenitor/stem cells from cord blood or multiple transplants as well as to better understand the mechanism of immune recovery. Clinical results will be evaluated through EUROCORD Registry.

Funding Scheme

THN - Thematic network contracts

Coordinator

ASSOCIATION POUR LA RECHERCHE SUR LES TRANSPLANTATIONS MEDULLAIRES
Address
Avenue Claude Vellefaux 1
75475 Paris
France

Participants (37)

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
Address
Avenue Claude Vellefaux 1
75475 Paris
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
France
Address
Avenue Victoria 3
75004 Paris
ASSOCIATION POUR LA RECHERCHE SUR LES TRANSPLANTATIONS MEDULLAIRES
France
Address
Avenue Claude Vellefaux 1
75475 Paris
ASSOCIATION POUR LA RECHERCHE SUR LES TRANSPLANTATIONS MEDULLAIRES
France
Address
Avenue Claude Vellefaux 1
75475 Paris
AZIENDA OSPEDALIERA OSPEDALE SAN MARTINO DI GENOVA E CLINICHE UNIVERSITARIE CONVENZIONATE
Italy
Address
Via Rosanna Benzi, 10
16132 Genova
CENTRE HOSPITALIER RÉGIONAL ET UNIVERSITAIRE DE NANCY
France
Address
Av. Du Maréchal De Lattre De Tassigny
54035 Nancy
CHAIM SHEBA MEDICAL CENTER
Israel
Address
Tel Hashomer
52621 Ramat Gan
ETABLISSEMENT DE TRANSFUSION SANGUINE DE BOURGOGNE / FRANCHE-COMTÉ
France
Address
Boulevard Alexandre Fleming 1
25020 Besancon
FONDAZIONE II SANGUE
Italy
Address
Via Francesco Sforza, 35
20122 Milano
GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH
Germany
Address
Ingolstaedter Landstrasse 1
85764 Neuherberg
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Address
Universitaetsstr. 1
40225 Duesseldorf
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
Address
Moorenstrasse, 5 Bldg 14.80
40225 Duesseldorf
HLA ET MDECINE
France
Address
Rue De L'ecole De Mtdecine 15, Institut Biomtdical
75006 Paris
HLA ET MÉDECINE
France
Address
Rue De L'ecole De Médecine 15, Institut Biomédical
75006 Paris
HLA ET MÉDECINE
France
Address
15,Rue De L'ecole De Médecine 15
75006 Paris
HOPITAL D'ENFANTS LA TIMONE
France
Address
Rue St Pierre, 264
13385 Marseille
HOSPITAL UNIVERSITARIO CLINICA PUERTA DE HIERRO
Spain
Address
San Martin De Porres 4
28035 Madrid
HOSPITAL UNIVERSITARIO DE LA FE SEVASA
Spain
Address
Avenida De Campanar 21
46009 Valencia
INSTITUT CATALA DE LA SALUT
Spain
Address
Paseo Valle De Hebron 119-129
08035 Barcelona
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Avenue Du Haut Leveque
33600 Pessac
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
75654 Paris
INSTITUT PAOLI CALMETTES - CENTRE RÉGIONAL DE LUTTRE CONTRE LE CANCER
France
Address
232,Boulevard Sainte Marguerite 232
13273 Marseille
INSTITUT PAOLI CALMETTES - CENTRE RÉGIONAL DE LUTTRE CONTRE LE CANCER
France
Address
232,Boulevard Sainte Marguerite 232
13273 Marseille
IRCCS POLICLINICO SAN MATTEO - ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO
Italy
Address
Piazzale Camillo Golgi 19
27100 Pavia
LEIDEN UNIVERSITY
Netherlands
Address
Albinusdreef 2
2333 AL Leiden
SCHNEIDER CHILDREN'S MEDICAL CENTER OF ISRAEL
Israel
Address
Kaplan Street 14
49202 Petach-tika
SERVEIS SANITARIS DE REFERENCIA - CENTRE DE TRANFUSIO I BANC DE TEIXITS
Spain
Address
Pg. Vall D'hebron 119-129
08035 Barcelona
SERVEIS SANITARIS DE REFERENCIA - CENTRE DE TRANFUSIO I BANC DE TEIXITS
Spain
Address
Pg. Vall D'hebron 119-129
08035 Barcelona
THE ANTHONY NOLAN BONE MARROW TRUST
United Kingdom
Address
Pond Street, Royal Free Hospital
NW3 2QG London
UNIVERSITE DE LIEGE*ULG
Belgium
Address
Place Du 20 Aout 7
4000 Liege
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Address

NE1 7RU Newcastle Upon Tyne
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Piazzale Aldo Moro, 5
00185 Roma
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Via Borelli 50
00161 Roma
UNIVERSITY OF TORINO
Italy
Address
44,Via Pietro Giuria 15
10125 Torino
UNIVERSITY OF TORINO
Italy
Address
Via Po 53
10124 Torino (Turin)
UNIVERSITÉ DE PARIS VII DENIS DIDEROT
France
Address
C/ol Université Denis Diderot, Place Jussieu 2, Ca
75251 Paris
WEIZMANN INSTITUTE OF SCIENCE
Israel
Address
Herzel Street 2
P.O.Box 26 Rehovot