Objective The cell membrane penetrating peptides, Capps, are designed and synthesized recently by the partners, and applied for cellular delivery of oligonucleotides. The aim of the present project is the design, synthesis and testing of novel on-viral modes of efficient target selective transport vectors based on CPPstrategy for delivery of DNA single and double strand cargos and applications ingénue therapy. For that, the mechanisms of cell penetration of Capps will be studied. Specific tissue, cell and sub cellular compartment targeting Capps will be developed for application in gene therapy. The libraries of Capps will besynthesised and tested with combination of iterative approach and high throughput screening. The biological effects of successful oligonucleotide delivery systems will be detected in vitro and in vivo, and used in a high-throughput assay of CPPoptimisation Fields of science medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomolecules Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator STOCKHOLM UNIVERSITET EU contribution No data Address UNIVERSITETSVAEGEN 10 10691 STOCKHOLM Sweden See on map Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all ASTRAZENECA UK LTD United Kingdom EU contribution No data Address Stanhope Gate 15 W1Y 6LN LONDON See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Michel-Ange 3 75794 PARIS See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address 46,Rue d' Ulm 46 Ecole Normale Superieure 75230 PARIS See on map Total cost No data CEPEP AB Sweden EU contribution No data Address S. Arrheniusvaegen 10891 STOCKHOLM See on map Total cost No data ECOLE NORMALE SUPERIEURE France EU contribution No data Address Rue d'Ulm 46, Ecole Normale Supérieure 75230 Paris See on map Total cost No data ESTONIAN BIOCENTRE Estonia EU contribution No data Address Riia st. 23 51010 TARTU See on map Total cost No data FORSCHUNGSVERBUND BERLIN E.V. Germany EU contribution No data Address Rudower Chaussee 17 12489 BERLIN See on map Total cost No data Medical Research Council (MRC) United Kingdom EU contribution No data Address 20 Park Crescent W1N 4AL London See on map Total cost No data UNIVERSITE DE MONTPELLIER II - SCIENCES ET TECHNIQUES DU LANGUEDOC France EU contribution No data Address Route de Mende, 1919 34293 MONTPELLIER See on map Total cost No data
