Human alveola echinococcosis caused by Echinococcus multilocularis is an emerging diseases in many parts of the world, especially Europe and China. In central Asia, there has been a dramatic increase in human cystic echinococcosis caused by E. granulosus since the collapse of the Soviet Union demonstrating the dramatic increase in the transmission of zoonotic disease between dogs and man. Although E. multilocularis infection is widespread in foxes, for example in Europe, high levels of human disease are often only seen when associated domestic dogs become infected with this parasite. Recently an intense focus of E. multilocularis infection in dogs has been observed in Eastern Kazakhstan. This is a disturbing trend as the close contact with humans makes the risk of human alveola echinococcosis high in this region. This project therefore aims to have a multidisciplinary approach to investigating the epidemiology of E. multilocularis in this area using ecological surveillance, human surveillance, mathematical modelling and geographical information systems, including remote sensing. This will result in a construction of risk and transmission models for alveola echinococcosis and hence the likelihood of human disease. It will also indicate the most effective means of controlling this extremely dangerous zoonosis. Such models will not only be of local significance but will be of fundamental importance in modelling the parasite transmission in other regions and in modelling other host-parasite systems.
M5 4WT Manchester