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Development of a technology to measure body fluid distribution in patients to improve dialysis treatment effieciency and patient comfort

Objective

The project aims at the solution of a clinically relevant problem Up to now about 25% of all dialysis patients suffer from acute complications (hemodynamic instability) during the treatment. Those instabilities are at least partly due to inadequate fluid balance as has been shown in several publications during the past 10 years. These instabilities provoke a tremendous discomfort to the patients suffering fainting, vomits and requiring relative long recovery periods. Apart from this discomfort, physiological problems affecting the patient's health are huge. It is needed to estimate with enough accuracy the fluid distribution in the patient during the dialysis treatment in order to take adequate countermeasures to avoid these instabilities. Up to date there are no suitable methods to measure on line this distribution with enough accuracy. This project proposes to use a non-invasive method that would allow to measure on line this fluid distribution. The RTD performers (NTE and UPC both based in Spain and TUG based in Austria) have been working in this method for 10 years and consider that this technology is ready to enter the applied research phase. The partners of the project propose to develop a system based in this technology and through a clinical essay to elaborate specific estimators for dialysis patients during treatment. The sector of instrumentation companies for dialysis is highly biased in big multinationals mostly based in the United States and small enterprises. Some of the most active small enterprises are based in Europe with important sales in the United States. The big companies are mainly focused in treatment-based instrumentation (filtration systems with control strategies) with no available systems to estimate body fluid distribution. The effort that the SME' s in Europe can perform to overcome the dominant position of the big multinationals is limited and thus programs like CRAFT become a necessary tool for them to compete in this multinational

Coordinator

IBP INSTRUMENTS GMBH
Address
Sutelstrasse 7 A
Hannover
Germany

Participants (5)

MSV MEDINZINISCHE SYSTEME GMBH
Germany
Address
Schiessmauer 11
Minfeld
AKERN SRL
Italy
Address
Via Lisbona 32/34
Pontassieve
NTE
Spain
Address
Can Male, S/n
Llica D Amunt
UNIVERSITAT POLITECNICA DE CATALUNYA
Spain
Address
Jordi Girona 31
Barcelona
TECHNISCHE UNIVERSITAET GRAZ
Austria
Address
Rechbauerstrasse 12
Graz