Objectif ION is a co-operative research proposal for the development of an innovative system capable of an efficient screening of candidate drugs on a wide set of targets (ion channels) involved in important neurological and psychiatric disorders, e.g. depression, Parkinson, epilepsy, migraine and pain. The proposers are a group of SMEs which includes technological companies and end users in the pharmaceutical sector. The RTD partners are required to provide the knowledge and the research capabilities to address the selection and optimization of the cellular targets and to validate the outcomes of the system in relation to the results of in vivo models of the pathologies of interest. However, an important contribution of the RTD partners will be to design a suite of innovative software agents for data analysis and experimental planning. The role of these agents is essential to achieve real high screening throughputs. The ION project will optimize the performance of a sequence of screening experiments instead of focusing on the execution of a single experiment. With respect to the current state of the art, the proposed development will introduce two important innovations. First, easy access to a large set of targets and to an efficient drug discovery process, exploiting a well designed and implemented library of starting molecular structures. Second, it will develop innovatively the analysis of the output and enable future experiments to be planned more effectively by introducing intelligent software agents interpreting the outcome of an experiment and planning the next experiment of a drug discovery screening sequence. The proposers estimate a large market in the EU, USA and Japan for their future products due to the expanding pharmaceutical research in the considered disorders which are still an unmet medical need. The proposing SMEs intend to present a common business plan in order to exploit the expected results worldwide. Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesdata sciencenatural sciencescomputer and information sciencesknowledge engineeringontologynatural sciencescomputer and information sciencessoftwarenatural sciencesbiological sciencesbiochemistrybiomoleculesproteins Programme(s) FP6-SME - Horizontal research activities involving SMEs: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) SME - Horizontal research activities involving SMEs Appel à propositions Data not available Régime de financement Cooperative - SMEs-Co-operative research contracts Coordinateur NEWRON PHARMACEUTICALS SPA Contribution de l’UE Aucune donnée Adresse Via Ariosto, 21 BRESSO (MI) Italie Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MULTI CHANNEL SYSTEMS MCS GMBH Allemagne Contribution de l’UE Aucune donnée Adresse Aspenhausstrasse 21 REUTLINGEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée SC IT ROMANIA ITR SRL Roumanie Contribution de l’UE Aucune donnée Adresse Street Pavlov nr.16 ap.4 CLUJ-NAPOCA Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée NIKEM RESEARCH SRL Italie Contribution de l’UE Aucune donnée Adresse Via Zambeletti, 25 BARANZATE DI BOLLATE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF DEBRECEN Hongrie Contribution de l’UE Aucune donnée Adresse EGYETEM TER 1 DEBRECEN Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée INSTITUTE OF PHARMACOLOGY, POLISH ACADEMY OF SCIENCES Pologne Contribution de l’UE Aucune donnée Adresse Smetna 12 KRAKOW Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ISTITUTO DI RECERCHE FARMACOLOGICHE "MARIO NEGRI" Italie Contribution de l’UE Aucune donnée Adresse Via Eritrea, 62 MILANO Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée POLITECNICO DI MILANO Italie Contribution de l’UE Aucune donnée Adresse Piazza L. da Vinci, 32 MILANO Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITÀ DEGLI STUDI DI FIRENZE Italie Contribution de l’UE Aucune donnée Adresse Piazza San Marco, 4 FIRENZE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée