Objective Inhibitors of metalloproteinases have shown a high therapeutic potency in preliminary clinical trials. However, unacceptable side-effects are associated, which are relative to recently discovered ADAMS and "non classical" effects of MMPs. This project aims at defining the best MMP inhibition profiles for cancer therapy by1) a comprehensive assessment of metalloprateinase activities and functions at both physiological and tumour progression level, i.e. by using first inhibition inhibitors as probe;2) designing new metalloproteinase inhibitors on the basis of inhibitor-enzyme complex 3-D structures and on the biological activities to be tackled;3) assessing the benefit of combining MMP inhibitors with serine proteases inhibitors designed on a similar basis. Fields of science medical and health sciencesclinical medicineoncology Programme(s) FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002 Topic(s) 1.1.1.-3. - Key action The "Cell factory" Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator UNIVERSITE DE LIEGE*ULG EU contribution No data Address PLACE DU 20 AOUT 7 4000 LIEGE Belgium See on map Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Laurent Fries 1 67404 ILLKIRCH GRAFFENSTADEN See on map Total cost No data COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Batiment 152, CEA/SACLAY 91191 GIF SUR YVETTE See on map Total cost No data COPENHAGEN UNIVERSITY HOSPITAL Denmark EU contribution No data Address Stransboulevarden 49 2100 KOEPENHAGEN See on map Total cost No data GERMAN CANCER RESEARCH CENTER Germany EU contribution No data Address Im Neuenheimer Feld 280 69120 HEIDELBERG See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address Rue Laurent Fries 1 67404 ILLKIRCH GRAFFENSTADEN See on map Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Am Klopferspitz 18 A 82152 MARTINSRIED See on map Total cost No data NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Greece EU contribution No data Address Panepistimiopolis Zographou 15771 ZOGRAPHOS, ATHENS See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address Trinity Lane, The Old Schools, CB2 1TN CAMBRIDGE See on map Total cost No data UNIVERSIDAD DE OVIEDO Spain EU contribution No data Address San Francisco 1-5 33003 OVIEDO See on map Total cost No data
