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Molecular Control of Erythropoiesis

Objective

Red blood cells (RBCs) mediate oxygen transport throughout the body, a function that is essential for life. RBCs are continuously produced via a process called erythropoiesis.
Anemias (insufficient numbers of functional RBCs), caused by failure of erythropoiesis, are a major cause of disease in the EC. The hereditary anemias constitute the most common human genetic disorders, with no effective cure yet. We propose an RTN “Molecular Control of Erythropoiesis” which will foster a multidisciplinary approach to clarify the important molecular mechanisms in normal and pathological erythropoiesis, with a view to develop novel therapies to cure the anemias. The RTN will generate a comprehensive molecular description of mechanisms governing erythropoiesis, from specification of hematopoietic stem cells in embryogenesis to terminal differentiation and post-mitotic maturation of red blood cels. For this, the RTN will use and further develop a large number of state of the art approaches in stem cell- and erythroid cell biology, including in vitro expansion, biochemistry of receptor / signal transducer complexes and transcription factors, and epigenetics. This mechanistic knowledge obtained within the RTN will be instrumental to devise intervention strategies for anemias and other erythroid disorders (e.g. dysplasias and leukemias). The RTN aims to (a) provide an international training platform for young scientists, (b) integrate European top-level genomics-oriented research in the area of hematopoietic disorders, and (c) serve as a link to industrial partners, with a view to enhance the career perspectives of young scientists in the European Research Area.

Call for proposal

FP6-2002-MOBILITY-1
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Funding Scheme

RTN - Marie Curie actions-Research Training Networks

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr. Molewaterplein 50
Rotterdam
Netherlands

Participants (6)

FORSCHUNGSINSTITUT FÜR MOLEKULARE PATHOLOGIE GES.M.B.H.
Austria
Address
Dr. Bohr-gasse 7
Vienna
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
Rue De Tolbiac, 101
Paris
INSTITUTE OF MOLECULAR MEDICINE
Portugal
Address
Avenida Prof. Egas Moniz
Lisboa
ISTITUTO SUPERIORE SANITÀ
Italy
Address
Viale Regina Elena 299
Roma
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20, Park Crescent
London
UNIVERSITY OF GRONINGEN
Netherlands
Address
Broerstraat 5
Groningen