Objective Red blood cells (RBCs) mediate oxygen transport throughout the body, a function that is essential for life. RBCs are continuously produced via a process called erythropoiesis.Anemias (insufficient numbers of functional RBCs), caused by failure of erythropoiesis, are a major cause of disease in the EC. The hereditary anemias constitute the most common human genetic disorders, with no effective cure yet. We propose an RTN Molecular Control of Erythropoiesis which will foster a multidisciplinary approach to clarify the important molecular mechanisms in normal and pathological erythropoiesis, with a view to develop novel therapies to cure the anemias. The RTN will generate a comprehensive molecular description of mechanisms governing erythropoiesis, from specification of hematopoietic stem cells in embryogenesis to terminal differentiation and post-mitotic maturation of red blood cels. For this, the RTN will use and further develop a large number of state of the art approaches in stem cell- and erythroid cell biology, including in vitro expansion, biochemistry of receptor / signal transducer complexes and transcription factors, and epigenetics. This mechanistic knowledge obtained within the RTN will be instrumental to devise intervention strategies for anemias and other erythroid disorders (e.g. dysplasias and leukemias). The RTN aims to (a) provide an international training platform for young scientists, (b) integrate European top-level genomics-oriented research in the area of hematopoietic disorders, and (c) serve as a link to industrial partners, with a view to enhance the career perspectives of young scientists in the European Research Area. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinehematologymedical and health sciencesclinical medicinetransplantationmedical and health sciencesclinical medicineoncologyleukemia Keywords Anemias bioinformatics imaging mouse models Genomics proteomics red blood cells thalasemias Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-1.1 - Marie Curie Research Training Networks (RTN) Call for proposal FP6-2002-MOBILITY-1 See other projects for this call Funding Scheme RTN - Marie Curie actions-Research Training Networks Coordinator ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM EU contribution No data Address Dr. Molewaterplein 50 ROTTERDAM Netherlands See on map Links Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all FORSCHUNGSINSTITUT FÜR MOLEKULARE PATHOLOGIE GES.M.B.H. Austria EU contribution No data Address Dr. Bohr-Gasse 7 VIENNA See on map Links Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE France EU contribution No data Address Rue de Tolbiac, 101 PARIS See on map Links Website Opens in new window Total cost No data INSTITUTE OF MOLECULAR MEDICINE Portugal EU contribution No data Address Avenida Prof. Egas Moniz LISBOA See on map Links Website Opens in new window Total cost No data ISTITUTO SUPERIORE SANITÀ Italy EU contribution No data Address Viale Regina Elena 299 ROMA See on map Links Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution No data Address 20, Park Crescent LONDON See on map Links Website Opens in new window Total cost No data UNIVERSITY OF GRONINGEN Netherlands EU contribution No data Address Broerstraat 5 GRONINGEN See on map Links Website Opens in new window Total cost No data
