Obiettivo The emergence of bacterial resistance has significantly underscored the importance of the discovery of novel classes of antibiotics. The common occurrence of multiple-drug resistant microbes, particularly in hospital settings, is cause for serious clinical concerns. Additionally, the existence of large cohorts of immune compromised patients and the need to utilise anti-infective agents prophylactic ally in their lifetime therapy compound the problem. Finally, the potential activities of dysfunctional nations and their disciples of death are chilling additions to the threat to the welfare of mankind. In 2002 Pfizer scientists reported the isolation of CJ-15, 696 and seven related fur pyridine antibiotics from the fermentation broth of the fungus Cladobotrywn varmint CL 12284. CJ-15, 696 showed modest activities against various Gram-positive bacteria including some drug resistant strains such as Staphylococcus aurous 01 A1 105, Staphylococcus progenies 02C1068, Staphylococcus pneumonia 02J1095 and Entercoccus faecal is 03A1069. S: pneumonia is frequently the causative agent for upper respiratory tract infections and is rapidly acquiring multi.- Drug resistance. Research will focus on the development of a new strategy for the total synthesis of CJ-15, 696. This will be amenable for the concise synthesis of fur pyridines as a general class and for the elaboration of analogues of the natural product to probe antibacterial activity. A concise and flexible total synthesis of CJ-15, 696 should make available a family of fur pyridine derivatives of potential value as novel antibiotics. The synthesis involves a new ring expansion process for the conversion of N-arenesulfonyl-ÿ-lactam derivatives, by reaction with emulates derived from y-lactones, into fur pyridine compounds. A library of analogues of the natural product will be prepared by parallel synthesis by use of arrays of ÿ-Iota and y-lactones precursors. Campo scientifico medical and health sciencesclinical medicinepneumologynatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsengineering and technologyindustrial biotechnologybioprocessing technologiesfermentation Parole chiave 15 696 CJ CJ-15 Claisen rearrangement Ireland Ireland-Claisen Total synthesis antibiotic asymmetric synthesis furopyridine organic chemistry rearrangement Programma(i) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Argomento(i) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Invito a presentare proposte FP6-2002-MOBILITY-5 Vedi altri progetti per questo bando Meccanismo di finanziamento EIF - Marie Curie actions-Intra-European Fellowships Coordinatore IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE Contributo UE Nessun dato Indirizzo South Kensington Campus LONDON Regno Unito Mostra sulla mappa Costo totale Nessun dato