Objectif Dendrite cells (DC) are highly specialized antigen presenting cells (APC) that are critical for the initiation of T cell-dependent immune responses. The antigen uptake functions of DC are mediated by the expression of specialized surface receptors some of them belonging to the animal lection family. Recently, many lection receptors have been identified on the DC surface. On the other hand, natural killer (NK) cells also express lection receptors on their surface that controls its activity by a balance between inhibitory and activating signals. These NK receptors are close related to the DC lectinreceptors. Little is known about the functions of these lections. It is thought that most lections on DC are involved in pathogen recognition and presentation, however they may also mediate cell-cell interactions. Some lection receptors on NK recognize MHC-I, but the binding specify of most of them, or whether they can bind carbohydrates or pathogens is not known. The purpose of this activity is the functional characterization of new lections receptors expressed on dendrite and NK cells. We will define its carbohydrate specify and pathogen binding, internalisation ability and pathways, analysis of a possible role in cell-cell interactions and study of signalling events operated by these receptors. Detailed understanding of these processes will create sophisticated tools to inhibit, induce, or modulate DC and NK-specific responses in various diseases such as cancer, auto-immunity and infection. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesmedical and health sciencesclinical medicineoncology Mots‑clés Carbohydrate binding Lectin receptor Natural Killer Cell Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Thème(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Appel à propositions FP6-2002-MOBILITY-5 Voir d’autres projets de cet appel Régime de financement EIF - Marie Curie actions-Intra-European Fellowships Coordinateur VRIJE UNIVERSITEIT MEDICAL CENTER Contribution de l’UE Aucune donnée Adresse De Boelelaan 1117 AMSTERDAM Pays-Bas Voir sur la carte Coût total Aucune donnée