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Modulation of osteoblast function by bioactive RGD-peptides arranged in nanotemplates

Objectif

The development of new methodologies in the field of material science and nanotechnology represents a useful tool to further explore and modify biomaterial design. Biocompatiblity is dependent on material-related factors, such as topography and surface chemistry, as well as cell adhesion and function. The focus of this multidisciplinary work is the creation of a system, which permits the study of bone cells adhesion and the regulation of their cellular activities. We propose to use novel chemical techniques to mimic the extracellular environment with bioactive peptides arranged into a rigid well-defined nano-template. We reason that these peptides should control cell attachment and activate integrin-dependent intracellular signaling pathways for bone cell proliferation, differentiation and death by apoptosis. The fellow will gain experience in material science, biophysical chemistry, biophysics, cell biology, and clinical research. The scientific and educational activity will be also embedded in a high quality research and education environment established at the Heidelberg University. Because of her past research experience, the candidate fits excellently to the named project where multidisciplinary skills and knowledge are needed. She will combine her abilities with the abilities of the group of Biophysical Chemistry at the University of Heidelberg, whose main focus is the control of cell adhesion by biophysics and nanotechnology. Until the end of the Marie Curie Fellowship in 2005 she will have the chance to gain enough qualifications to become an associated faculty member in an European Institute or University. The European Community is investing into a young researcher, which will have great potential to connect European research activities in future years. Thus, her will for worldwide mobility is enhancing her own scientific excellence which than will be carried forward to other young scientists and research institutions in Europe.

Appel à propositions

FP6-2002-MOBILITY-5
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Coordinateur

UNIVERSITY OF HEIDELBERG
Contribution de l’UE
Aucune donnée
Adresse
INF 253
HEIDELBERG
Allemagne

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Coût total
Aucune donnée