Objetivo Most human pathogenic fungi have a dual life cycle involving saprotrophic growth in the environment, alternated by an invasive phase. The formation of propagules enable the fungus to leave the host is necessary and can be viewed as a hallmark of a pathogen . In contrast, opportunists do not have any means of transmission. The model organism Pseudallescheria boydii, a fungal opportunist, colonises man-made environments, such as polluted soil and ponds, industrial filters and sewage in high frequencies. This f ungus is one of the emerging, therapy-refractory agents of hospital infections. Opportunists are taking advantage of environmental conditions which are adverse for most other organisms, e.g. assimilation of toxic compounds, oligotrophism, or thermotoleran ce. When these conditions are provided in excess, e.g. in man-made habitats, up-scaled niches serve as stepping stones for adaptation, now in the direct vicinity of humans. As adaption and evolution towards increased virulence can take place in the host a s well as in the environment. P. boydii is prone to reach another level of virulence in the human host. This may be driven by changes in the environment or by the adaption to the human host. When the environment becomes more permissive, it allows for selec tion of the most vigorously reproducing genotypes and thus provides an enormous window of opportunity for the species which overrules the trade-offs for invasion. A new balance between environmental and invasive cycles is probable to lie on a higher level of virulence. In the proposed study we will evaluate computed models of the cost effectiveness of pathogen abilities in opportunistic fungi. Together with the description of population dynamics this will serve to establish tools for effective risk assessme nt and for better understanding of the evolution of fungal virulence. Competition experiments with the model organism P. boydii will be carried out, providing basic data for computer-aided modelling. Ámbito científico natural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesecologynatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health scienceshealth sciencesnutrition Programa(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Tema(s) MOBILITY-1.3 - Marie Curie Host Fellowships - Transfer of knowledge (TOK) Convocatoria de propuestas FP6-2002-MOBILITY-3 Consulte otros proyectos de esta convocatoria Régimen de financiación TOK - Marie Curie actions-Transfer of Knowledge Coordinador CENTRAALBUREAU VOOR SCHIMMELCULTURES Aportación de la UE Sin datos Dirección Uppsalalaan 8 UTRECHT Países Bajos Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITAET INNSBRUCK Austria Aportación de la UE Sin datos Dirección Innrain 52 INNSBRUCK Ver en el mapa Coste total Sin datos UNIVERSITEIT VAN AMSTERDAM Países Bajos Aportación de la UE Sin datos Dirección Spui 21 AMSTERDAM Ver en el mapa Coste total Sin datos