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Identification of new cancer susceptibility genes by linkage analyses in Polish families with aggregation of breast or colorectal cancers

Project information

Grant agreement ID: 510114

  • Start date

    1 September 2004

  • End date

    31 August 2008

Funded under:

FP6-MOBILITY

  • Overall budget:

    € 251 352

  • EU contribution

    € 251 352

Coordinated by:

POMERANIAN MEDICAL ACADEMY

Poland

Objective

International Hereditary Cancer Centre (IHCC), Szczecin, Poland is institution organised in order to perform basic and clinical studies on hereditary cancer. During 11 years of its activity, IHCC achieved several world-class goals. One of them is registrat ion of more than 3000 of families with strong aggregation of different types of malignancies. In around 1000 of them it was possible to find constitutional mutations in one of major cancer susceptibility genes such as BRCA1, BRCA2, MSH2, MLH1, MSH6, APC an d others. However, in around 2000 of registered families constitutional mutations have not been detected. In order to achieve it and to use the enormous unique potential of IHCC in identification of new cancer susceptibility genes, it is crucial to develop in this centre linkage analyses - one of the most powerful methodology of finding genes involved in pathogenesis of inherited disorders. World-class scientists - D. Goldgar from Lyon and P. Peltomaki from Helsinki (known fortheir great contribution in wor k on identification of BRCA1, BRCA2 and MSH2 genes) expressed their interest instudies with the use of linkage analyses aimed to identify novel cancer susceptibility genes in families registered by IHCC with strong aggregations of breast and colorectal can cers.The complementary experiments will be performed on 47 large families (including 6 with biological samples available from at least 10 affected relatives) at IHCC (by experienced researcher recruited for 2 years and a few members of IHCC permanent staff ), Lyon and Helsinki (by two outgoing post-doc fellows from IHCC) under supervision of D. Goldgar and P. Peltomaki and project co-ordinator.

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Coordinator

POMERANIAN MEDICAL ACADEMY

Address

Ul. Rybacka 1
Szczecin

Poland

Participants (2)

INTERNATIONAL AGENCY FOR RESEARCH ON CANCER

France

UNIVERSITY OF HELSINKI (DUPLI USE 999016982)

Finland

Project information

Grant agreement ID: 510114

  • Start date

    1 September 2004

  • End date

    31 August 2008

Funded under:

FP6-MOBILITY

  • Overall budget:

    € 251 352

  • EU contribution

    € 251 352

Coordinated by:

POMERANIAN MEDICAL ACADEMY

Poland