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A Hybrid Approach for Bone and Cartilage Tissue Engineering using Natural Origin Scaffolds, Progenitor Cell and Growth Factors

Objective

This project aims to provide new tissue engineering technologies for therapeutic treatments, which will ultimately have major social impact by contributing to the challenge of providing lifelong health for our society at an affordable cost. The main aim is the development of advanced functional materials that are needed for improved quality of life of thousands of patients suffering from cartilage or bone tissue loss or malfunctioning. The improved therapy suggested herein will result in a decreased morbidity and mortality of patients with reduction of the overall costs in EU healthcare. A major objective is the development of tissue engineering (TE) products that can be used for bone TE, cartilage TE or for an osteochondral TE strategy. Natural origin scaffolds mainly based on algae & chatoyant will be used for bone andcartilage. Cewrmaic bi-physic calcium phosphates scaffolds will be obtain from mineralised red algae. For theosteochondral approach, specific technologies will be developed to produce complex bi-material (polymer/ceramic) constructs. An all range of adequate processing techniques to obtained suitable scaffolds will be developed. One of the main innovations will be the development and use of specific software packages for designing patient specific scaffolds that will be combined with the production of the scaffolds by means of 3D plotting methodologies. Other techniques will include melt based processing and solvent-based techniques. The scaffolds will also be loaded with arrange of growth factors including several bone-morph genetic proteins other GF in the TGF- family. Primary cells and progenitor cells obtained from animals and later on from human patients will be used to develop the tissue-engineered products. Cell culturing methodologies will be optimised and specific ways of controlling the cultures evolution into the desired phenotypes will be developed. In-vivo functionality assessment experiments will also be carried out.

Call for proposal

FP6-2002-NMP-1
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

UNIVERSIDADE DO MINHO
Address
The Rectory, Largo Do Paco
Braga
Portugal

Participants (6)

ENVISIONTEC GMBH
Germany
Address
Elbestrasse 10
Marl
JOHANNES GUTENBERG UNIVERSITAET MAINZ
Germany
Address
Saarstrasse 21
Mainz
LUDWIG BOLTZMANN GESELLSCHAFT
Austria
Address
Operngasse 6, 5. Stock
Wien
MATERIALISE NV
Belgium
Address
Technologielaan 15
Leuven
QUEEN'S UNIVERSITY BELFAST
United Kingdom
Address
University Road
Belfast
ROTES KREUZ LANDESVERBAND OBEROESTERREICH
Austria
Address
Koernerstrasse 28
Linz