Sino-European Project on SARS Diagnostics and Antivirals

Informazioni relative al progetto

SEPSDA

ID dell’accordo di sovvenzione: 3831

Data di avvio 1 Maggio 2004

Data di completamento 30 Aprile 2008

Finanziato da

• Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006.

Costo totale € 3 338 512,00

Contributo UE € 1 887 608,00

Coordinato da

UNIVERSITY OF LUEBECK
Germany

Obiettivo

Combatting and eventually eradicating the new coronavirus causing Severe Acute Respiratory Syndrome (SARS) requires specific and efficient antiviral drugs and improved diagnostics. The Sino-European Project on SARS Diagnostics and Antivirals (SEPSDA) is an integrated project that applies modern biotechnical technology for the generation of improved diagnostics and of lead compounds for antiviral drugs. SEPSDA brings together leading SARS researchers from Germany, Denmark, Poland, and China, who together have an excellent publication record on the molecular biology of SARS coronavirus (SARS-CoV). Several of the existing anti-SARS drug leads as well as the first antibody-based diagnostic kit were created by members of SEPSDA. Participation of four leading laboratories in China brings SEPSDA in the unique position of having access to samples from Chinese patients at various stages of disease. Serological studies will lead to improved SARS diagnostics. Analysis of the genome and the proteome of SARS coronavirus by sequencing and advanced bioinformatics will further determine the genetic variability of the virus isolates and identify new possible targets for therapeutic intervention, both at the RNA and the protein level. SEPSDA aims at determining the three-dimensional structures of all soluble SARS-CoV proteins or domains thereof. This structural genomics approach will provide the basis for the virtual screening of large compound databases, including those containing Chinese traditional medicines, for molecules potentially interfering with the function of the viral proteins or their interaction partners in the host cell. Candidate inhibitors will be tested in cell culture and improved by synthetic chemistry. After patenting, the lead compounds will be offered to an industrial platform on SARS, yet to be created, which should form an interface between SEPSDA and the pharmaceutical industry.

Campo scientifico

• medical and health sciences › health sciences › infectious diseases › RNA viruses › coronaviruses

Parole chiave

• Cristallography

Programma(i)

• FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006.

Argomento(i)

• POLICIES-2.2 - Public health issues, including epidemiology contributing to disease prevention and responses to emerging rare and communicable diseases, allergies, procedures for secure blood and organ donations, non-animal test methods

Invito a presentare proposte

FP6-2003-SSP-2-SARS
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Meccanismo di finanziamento

STREP - Specific Targeted Research Project

Coordinatore

UNIVERSITY OF LUEBECK

• Contributo UE: Nessun dato
• Indirizzo: Ratzeburger Allee 160 ; LUEBECK ; Germania
• Costo totale: Nessun dato

Partecipanti (7)

UNIVERSITY OF AARHUS

Danimarca

• Contributo UE: Nessun dato
• Indirizzo: Nordre Ringgade 1 ; AARHUS C
• Costo totale: Nessun dato

BIOINFOBANK INSTITUTE

Polonia

• Contributo UE: Nessun dato
• Indirizzo: Limanowskiego 24/a ; POZNAN
• Costo totale: Nessun dato

EUROIMMUN, MEDIZINISCHE LABORDIAGNOSTIKA AG

Germania

• Contributo UE: Nessun dato
• Indirizzo: Seekamp 31 ; LUEBECK
• Costo totale: Nessun dato

TSINGHUA UNIVERSITY

Cina

• Contributo UE: Nessun dato
• Indirizzo: Tsinghua University ; BEIJING
• Costo totale: Nessun dato

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Cina

• Contributo UE: Nessun dato
• Indirizzo: 555 Zu Chong Zhi Road ; SHANGHAI
• Costo totale: Nessun dato

NATIONAL CENTER FOR CLINICAL LABORATORY, P.R.C.

Cina

• Contributo UE: Nessun dato
• Indirizzo: NO.1 Dahua Road,Dongdan ; BEIJING
• Costo totale: Nessun dato

BEIJING GENOMICS INSTITUTE, CHINESE ACADEMY OF SCIENCES

Cina

• Contributo UE: Nessun dato
• Indirizzo: B-6 Airport Industrial Zone ; BEIJING
• Costo totale: Nessun dato