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European Renal Genome Project

Objective

Diseases of the kidney represent a major cause of morbidity and mortality in Europe. The elderly are disproportionately affected, but renal disease is also a condition that severely affects children. An estimated 4.5 Million Europeans suffer from renal disorders. The death rate in patients with renal failure is 20% annually. This disease burden and its challenge for our societies is the focus of this proposal. Elucidation of the human and other genomes heralds a new era in biomedical research offering unprecedented opportunities to understand disease processes and to identify strategies to improve health. We will embrace these opportunities and implement an interdisciplinary research program, the European Renal Genome Project (EuReGene) that integrates European excellence in research relevant to renal development, pathophysiology and genetics. Our goal is to discover genes responsible for renal development and disease, their proteins and their actions. To achieve this goal, we have established a consortium of leading scientists, clinicians and SME partners that will focus on the development of novel technologies and discovery tools in functional genomics and their application to kidney research. We will rely on comparative genomic studies in many systems that provide utilitarian models ranging from zebrafish, to Xenopus, to mice, to rats. Our studies will be performed at different levels including the gene, the cell, the organ and the organism. Ultimately, identification of disease genes will lead to a better understanding of renal disease processes, to improved diagnosis and to new concepts in therapy. Our program will establish a paradigm for an integrated post-genomic approach to analyze renal disease-related developments that may be transferred to other organ systems or disease entities in the future.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

IP - Integrated Project

Coordinator

MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN
Address
Robert-roessle-str., 10
740238 Berlin
Germany

Participants (13)

MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Crescent
London
SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZURICH
Switzerland
Address
Rämistrasse 101
Zürich
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Address
Via Eritrea, 62
Milano
UNIVERSITY OF ZURICH
Switzerland
Address
Winterthurerstr. 190
Zurich
UNIVERSITY OF OULU
Finland
Address
Pentti Kaiteran Katu 1
Oulu
UNIVERSITY OF AARHUS
Denmark
Address
Ndr. Ringgade 1
Aarhus C
CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
RECEPTICON APS
Denmark
Address
Science Park Gustav Wieds Vej 10
Aarhus
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
Germany
Address
Geschwister-scholl-platz 1
München
MAX-PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN, MPI OF EXPERIMENTAL ENDOCRINOLOGY
Germany
Address
Hofgartenstrasse 8
Muenchen
UNIVERSITÉ CATHOLIQUE DE LOUVAIN
Belgium
Address
Place De L'université, 1
Louvain-la-neuve
ZENTRUM FÜR MOLEKULARE NEUROBIOLOGIE, UNIVERSITÄT HAMBURG
Germany
Address
Martinistrasse 52
Hamburg