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Biosimulation - A New Tool in Drug Development

Objective

International competition in the pharmaceutical industry is increasingly becoming a competition with respect to the ability to understand complex biological processes and exploit the rapidly growing amount of biological information. The methods that are currently applied in the development of new medicines suffer from the lack of effective means to evaluate, combine, and accumulate biological knowledge. Essential improvements must involve the use of computational models that can provide a dynamic and more quantitative description of the relevant biological, pathological, and pharmacokinetic processes. We propose to establish a Network of Excellence that can restructure and strengthen the area of biosimulation by focusing on the development of professional, physiologically based models that can help the pharmaceutical industry develop safe and effective drugs at significantly lower costs. The modelling approach is strongly recommended by the American Food and Drug Administration that already uses mathematical models in its evaluation of applications for drug approval. Academic institutions in Europe have significant expertise in biological modelling, and several groups are individually at the research front in their specific areas. At the present, however, the research is strongly fragmented, and the industry itself has relatively few qualified experts in the field. The Network will provide a new forum for collaboration across disciplinary boundaries as well as between industry and academia. The BioSim Network involves 26 leading academic groups, 9 small and medium-sized enterprises, 1 large pharmaceutical industry, and the Danish, Spanish, Dutch, and Swedish regulatory agencies. The Network collaborates with the European Federation for Pharmaceutical Sciences (EUFEPS).

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

NoE - Network of Excellence

Coordinator

TECHNICAL UNIVERSITY OF DENMARK
Address
Anker Engelundsvej 101
Kgs. Lyngby
Denmark

Participants (38)

VRIJEUNIVERSITEIT AMSTERDAM/FACULTEIT AARD- EN LEVENSWETENSCHAPPEN/IMC
Netherlands
Address
De Boelelaan 1087
Amsterdam
THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
PHILIPPS-UNIVERSITAET MARBURG
Germany
Address
Biegenstrasse 10
Marburg
UNIVERSITY OF MANCHESTER
United Kingdom
Address
Oxford Road
Manchester
UNIVERSITAET POTSDAM
Germany
Address
Am Neuen Palais 10
Potsdam
FORSCHUNGSZENTRUM JUELICH GMBH
Germany
Address
Leo-brandt Str.
Juelich
LUND UNIVERSITY
Sweden
Address
Paradisgaten 5C
117 Lund
LINKOEPING UNIVERSITY
Sweden
Address

Linkoeping
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Avenue F D Roosevelt 50
Bruxelles
UNIVERSITAT DE VALENCIA, ESTUDI GENERAL
Spain
Address
Avda. Blasco Ibanez 13
22085 Valencia
UNIVERSITY OF COPENHAGEN
Denmark
Address
Noerregade 10
Copenhagen
UNIVERSITY OF WARWICK
United Kingdom
Address
-
Coventry
UNIVERSITY OF SHEFFIELD
United Kingdom
Address
Western Bank
Sheffield
TECHNISCHE UNIVERSITAET OF DRESDEN
Germany
Address
Helmholtzstr. 10
Dresden
INSITUTE OF EXPERIMENTAL PHARMACOLOGY, SLOVAK ACADEMY OF SCIENCES
Slovakia
Address
Dubravska Cesta 9
Bratislava
INSTITUTE OF ENZYMOLOGY, HUNGARIAN ACADEMY OF SCIENCE
Hungary
Address
Karolina U 29
Budapest
CHARITE UNIVERSITATSMEDIZIN BERLIN, INSTITUTE OF MEDICAL INFORMATICS
Germany
Address
Schumannstrasse 20/21
Berlin
UNIVERSITAT DE LES ILLES BALEARS
Spain
Address
Ed.son Lledo, Campus Uib
Palma De Mallorca
UNIVERSITY OF BORDEAUX 2 - VICTOR SEGALEN
France
Address
146, Rue Leo-saignat
Bordeaux
UNIVERSITY OF LEEDS
United Kingdom
Address
Woodhouse Lane
Leeds
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
Rue De Tolbiac, 101
Paris
EML RESEARCH GGMBH
Germany
Address
Schloss-wolfsbrunnenweg 33
Heidelberg
SIMCYP LIMITED
United Kingdom
Address
The Innovation Centre, 217 Portobello
Sheffield
INNETICS AB
Sweden
Address
Teknikringen 7
Linkoping
MXM LABORATORIES SA
France
Address
2720 Chemin St Bernard
Valauris
LAXDALE LIMITED
United Kingdom
Address
Kings Park House, Laurelhill Business Park
Stirling
SEMGINE GMBH
Germany
Address
Dieffenbachstr. 33C
Berlin
FRAUNHOFER-CHALMERS RESEARCH CENTRE FOR INDUSTRIAL MATHEMATICS
Sweden
Address
Chalmers Science Park
Goeteborg
SOLVO BIOTECHNOLOGY INC.
Hungary
Address
Beke 5/A
Szeged
ZEALAND PHARMA A/S
Denmark
Address
Smedeland 26B
Glostrup
NOVO NORDISK A/S
Denmark
Address
Novo Alle 1
Bagsvaerd
DANISH MEDICINES AGENCY
Denmark
Address
Axel Heides Gade 1
Copenhagen
AGENCIA ESPANOLA DE MEDICAMENTOS Y PRODUCTOS SANITARIOS
Spain
Address
Calle Alcala 56
Madrid
MEDICINES EVALUATION BOARD
Netherlands
Address
Kalvermarkt 53
The Hague
MEDICAL PRODUCTS AGENCY
Sweden
Address
Dag Hammarsjoelds Vag 42
Uppsala
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Germany
Address
Seminarstr. 2
Heidelberg
THE UNIVERSITY OF EDINBURGH
United Kingdom
Address
Old College, South Bridge
Edinburgh
UNIVERSITÀ DEGLI STUDI DI PADOVA
Italy
Address
Via Viii Febbraio 1848, 2
Padova