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INTEGRATING GENOMICS-BASED APPLICATIONS TO EXPLOIT ACTINOMYCETES AS A RESOURCE FOR NEW ANTIBIOTICS

Project information

Grant agreement ID: 5224

  • Start date

    1 January 2005

  • End date

    31 December 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 11 350 858

  • EU contribution

    € 9 384 133

Coordinated by:

UNIVERSITY OF WALES, SWANSEA

United Kingdom

Objective

ActinoGEN is an integrated project aimed at developing novel genomics-based approaches to exploit hitherto overlooked genetic resources for new antibiotics. Drug discovery will focus on (1) accessing new antibiotic biosynthetic pathways from diverse actinomycetes that have yet to be cultured; (2) activating cryptic pathways from well-characterised actinomycetes; and (3) engineering novel hybrid antibiotics by combinatorial biosynthesis. To greatly accelerate the drug discovery process, a parallel strategy will be to engineer generic hosts optimised to produce high antibiotic yields. With the complete genome sequence of the model actinomycete, Streptomyces coelicolor, and mobilization of a pan-European effort to apply newly developed multidisciplinary post-genomic technologies, a holistic understanding of the physiology and regulation of antibiotic biosynthesis is achievable for the first time. This will, in turn, permit rational intervention to engineer generic hosts for high-yield antibiotic production. This synergy of discovery linked to overproduction will place the European biotechnology sector at the forefront of developing much-needed new antibiotics to combat multi-drug resistant pathogens.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITY OF WALES, SWANSEA

Address

Singleton Park
Swansea

United Kingdom

Participants (17)

DIPARTIMENTO DI BIOLOGIA CELLULARE E DELLO SVILUPPO, UNIVERSITA DI PALERMO

Italy

EBERHARD KARLS-UNIVERSITÄT TÜBINGEN

Germany

ENTRECHEM SL

Spain

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

INSTITUTE OF BIOTECHNOLOGY OF LEÓN

Spain

INSTITUTE OF MICROBIOLOGY, ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

JOHN INNES CENTRE

United Kingdom

LIBRAGEN

France

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

SEOUL NATIONAL UNIVERSITY

South Korea

TECHNICAL UNIVERSITY OF DENMARK

Denmark

TECHNISCHE UNIVERSITAET BERLIN

Germany

THE UNIVERSITY OF MANCHESTER

United Kingdom

UNIVERSIDAD DE OVIEDO

Spain

UNIVERSITE PARIS-SUD

France

UNIVERSITY OF SURREY

United Kingdom

UNIVERSITY OF WARWICK

United Kingdom

Project information

Grant agreement ID: 5224

  • Start date

    1 January 2005

  • End date

    31 December 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 11 350 858

  • EU contribution

    € 9 384 133

Coordinated by:

UNIVERSITY OF WALES, SWANSEA

United Kingdom