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Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome

Objective

The European Union, like the rest of the world, is faced with an epidemic of the related chronic conditions, Type 2 diabetes, obesity and the metabolic syndrome. Unless steps are taken to alleviate this crisis, the cost of treating the long-term consequences of these conditions could overwhelm our healthcare systems. Although genetic factors increase the risk of developing these conditions, their rapid current global rise must be due to environmental factors. Obesity and insulin resistance, both precursors of Type 2 diabetes, arise due to an imbalance between energy intake and energy expenditure. This in turn may be due to two features of the modern urban lifestyle: (i) frequent consumption of processed foods with high energy and low fibre content; (ii) reduction in the amount of exercise taken due to changes in social and transport patterns. It is now well established that regular exercise, combined with an improved diet, provides protection against the development of these conditions, as well as a first line of treatment. The aim of the consortium is to provide a better understanding of the molecular mechanisms involved, especially in terms of the signalling pathways and changes in gene expression, that provide these beneficial effects of exercise. Our consortium will address these questions using a range of multidisciplinary approaches including:
(i) molecular and cell biology;
(ii) studies of animal models;
(iii) physiological studies in human volunteers of both genders;
(iv) epidemiological and genetic studies of large human populations of both genders.

The consortium includes companies in the areas of food production, pharmaceuticals and biotechnology, who will ensure rapid application of the findings made. Improved understanding of the molecular basis of the beneficial effects of exercise will yield applications not only in these industries, but will also provide a sounder theoretical basis for policies regarding promotion of good health.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITY OF DUNDEE
Address
Nethergate
Dundee
United Kingdom

Participants (25)

RIGSHOSPITALET
Denmark
Address
Blegdamsvej 9
Copenhagen
CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY
Belgium
Address
Avenue Hippocrate 75
ICP-UCL 75.29 Brussels
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Address
101, Rue De Tolbiac
Paris
UNIVERSITY OF COPENHAGEN,
Denmark
Address
Nørregade 10
2177 Copenhagen K
FOUNDATION FOR RESEARCH IN HEALTH EXERCISE AND NUTRITION
Finland
Address
Haapaniementie 16
Kuopio
NOVO NORDISK A/S
Denmark
Address
Novo Allé
Bagsværd
ASTRAZENECA
Sweden
Address
Västra Mälarehamnen 9
Södertälje
MEDICAL RESEARCH COUNCIL
United Kingdom
Address
20 Park Cresent
London
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano, 117
Madrid
UNIVERSITAT AUTONOMA DE BARCELONA
Spain
Address
Campus Universitari Uab
Bellaterra (Cerdanyloa Del Valles)
INSTITUTE OF PHYSIOLOGY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC
Czechia
Address
Videnska 1083
Prague
UNIVERSITY COLLEGE LONDON
United Kingdom
Address
Gower Street
London
UNIVERSITEIT MAASTRICHT, CARDIOVASCULAR RESEARCH INSTITUTE MAASTRICHT
Netherlands
Address
Universiteitssingel 50
616 Maastricht
ISTITUTO VENETO DI MEDICINA MOLECOLARE - CENTRO DI RICERCA DELLA FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA
Italy
Address
Via Orus 2
Padova
KAROLINSKA INSTITUTET
Sweden
Address
X
Stockholm
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
Munich
UNIVERSITY OF NOTTINGHAM
United Kingdom
Address
University Park
Nottingham
MEDICAL UNIVERSITY OF BIALYSTOK
Poland
Address
Kilinskiego 1
Bialystok
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5 C
117 Lund
UNILEVER UK CENTRAL RESOURCES LTD
United Kingdom
Address
Unilever House, Blackfriars
London
CAMBRIDGE NEUROTECHNOLOGY LIMITED
United Kingdom
Address
Upper Pendrill Court, Ermine Street North Papworth Everard
Cambridge
RHEOSCIENCE
Denmark
Address
Glerupvej 2
Roedovre
UNIVERSITY JOSEPH FOURIER GRENOBLE 1
France
Address
621, Avenue Centrale - Domaine Universitaire
BP 53 Grenoble
STENO DIABETES CENTER A/S
Denmark
Address
Niels Steensens Vej 2
0396 Gentofte
SWISS FEDERAL INSTITUTE OF TECHNOLOGY, ZÜRICH
Switzerland
Address
Rämistrasse 101
Zurich