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Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome

Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome

Objective

The European Union, like the rest of the world, is faced with an epidemic of the related chronic conditions, Type 2 diabetes, obesity and the metabolic syndrome. Unless steps are taken to alleviate this crisis, the cost of treating the long-term consequences of these conditions could overwhelm our healthcare systems. Although genetic factors increase the risk of developing these conditions, their rapid current global rise must be due to environmental factors. Obesity and insulin resistance, both precursors of Type 2 diabetes, arise due to an imbalance between energy intake and energy expenditure. This in turn may be due to two features of the modern urban lifestyle: (i) frequent consumption of processed foods with high energy and low fibre content; (ii) reduction in the amount of exercise taken due to changes in social and transport patterns. It is now well established that regular exercise, combined with an improved diet, provides protection against the development of these conditions, as well as a first line of treatment. The aim of the consortium is to provide a better understanding of the molecular mechanisms involved, especially in terms of the signalling pathways and changes in gene expression, that provide these beneficial effects of exercise. Our consortium will address these questions using a range of multidisciplinary approaches including:
(i) molecular and cell biology;
(ii) studies of animal models;
(iii) physiological studies in human volunteers of both genders;
(iv) epidemiological and genetic studies of large human populations of both genders.

The consortium includes companies in the areas of food production, pharmaceuticals and biotechnology, who will ensure rapid application of the findings made. Improved understanding of the molecular basis of the beneficial effects of exercise will yield applications not only in these industries, but will also provide a sounder theoretical basis for policies regarding promotion of good health.

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Coordinator

UNIVERSITY OF DUNDEE

Address

Nethergate
Dundee

United Kingdom

Administrative Contact

Grahame David HARDIE (Prof.)

Participants (25)

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RIGSHOSPITALET

Denmark

CHRISTIAN DE DUVE INSTITUTE OF CELLULAR PATHOLOGY

Belgium

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

UNIVERSITY OF COPENHAGEN,

Denmark

FOUNDATION FOR RESEARCH IN HEALTH EXERCISE AND NUTRITION

Finland

NOVO NORDISK A/S

Denmark

ASTRAZENECA

Sweden

MEDICAL RESEARCH COUNCIL

United Kingdom

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

UNIVERSITAT AUTONOMA DE BARCELONA

Spain

INSTITUTE OF PHYSIOLOGY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC

Czechia

UNIVERSITY COLLEGE LONDON

United Kingdom

UNIVERSITEIT MAASTRICHT, CARDIOVASCULAR RESEARCH INSTITUTE MAASTRICHT

Netherlands

ISTITUTO VENETO DI MEDICINA MOLECOLARE - CENTRO DI RICERCA DELLA FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA

Italy

KAROLINSKA INSTITUTET

Sweden

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

UNIVERSITY OF NOTTINGHAM

United Kingdom

MEDICAL UNIVERSITY OF BIALYSTOK

Poland

LUNDS UNIVERSITET

Sweden

UNILEVER UK CENTRAL RESOURCES LTD

United Kingdom

CAMBRIDGE NEUROTECHNOLOGY LIMITED

United Kingdom

RHEOSCIENCE

Denmark

UNIVERSITY JOSEPH FOURIER GRENOBLE 1

France

STENO DIABETES CENTER A/S

Denmark

SWISS FEDERAL INSTITUTE OF TECHNOLOGY, ZÜRICH

Switzerland

Project information

Grant agreement ID: 5272

  • Start date

    1 January 2005

  • End date

    31 December 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 17 335 982

  • EU contribution

    € 12 695 377

Coordinated by:

UNIVERSITY OF DUNDEE

United Kingdom