Objective Excitotoxicity (EXC), neuronal death from excessive stimulation, contributes to a plethora of neurodegenerative conditions including cerebral ischemia and seizure-induced death. Stress activated protein kinases (SAPKs) of the JNK and p38 families have been identified as novel mediators of EXC death which is mainly executed by existing proteins demanding post-translational modifications. STRESSPROTECT members have (a) demonstrated that specific TAT-fused peptide inhibitors of the JNK pathway confer lasting neuroprotection against seizure induced and ischemic cell death with an extended therapeutic window, (b) analysed the individual apoptotic actions of SAPK isoforms, and (c) provided important insights into signalling from glutamate-receptors. STRESSPROTECT gathers the European elite for SAPK signalling in the brain and for neuroprotection against EXC by pharmacological intervention in these pathways, and proposes a novel therapeutic concept against EXC. STRESSPROTECT provides synergistic research activities addressing the organisation and function of SAPKs signalling with molecular genetics, proteomics, signalosome-analysis, and molecular pharmacology including pharmacokinetics. At the end STRESSPROTECT has identified EXC-related SAPK signalosomes and delivered novel inhibitor peptides against SAPK sig-nalling underlying EXC-mediated degeneration. STRESSPROTECT will identify (a) proteins in upstream regulatory complexes induced by EXC, (b) the downstream targets mediating EXC and (c) specific protein-protein interaction sequences as targets for functional inhibition of SAPK signalling; STRESSPROTECT (d) extend the neuroprotective value of existing inhibitory peptides, (e) develop novel TAT-fused peptides inhibiting particular loci in the stress kinase pathways, (f) devise ways of targeting peptides specifically into EXC-affected cells and (g) carefully defines the risk-benefit ratio prospective to implementation in clinical trials. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsmedical and health sciencesbasic medicineneurologystroke Keywords excitotoxicity neuropharmacology signalosomes Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-2.1.3-6 - Excitotoxic neuronal cell death Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator UNIVERSITAETSKLINIKUM SCHLESWIG-HOLSTEIN, CAMPUS KIEL EU contribution No data Address Brunswikerstrasse 10 KIEL Germany See on map Links Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all XIGEN SA Switzerland EU contribution No data Address Falaises 1 LAUSANNE See on map Links Website Opens in new window Total cost No data PORSOLT SAS France EU contribution No data Address ZA des Suhards LE GENEST SAINT-ISLE See on map Links Website Opens in new window Total cost No data UNIVERSITÉ DE LAUSANNE Switzerland EU contribution No data Address Bâtiment du Rectorat et de l'Administration (BRA) LAUSANNE See on map Links Website Opens in new window Total cost No data AABO AKADEMI UNIVERSITY, TURKU CENTRE FOR BIOTECHNOLOGY Finland EU contribution No data Address Domkyrkotorget 3 TURKU See on map Links Website Opens in new window Total cost No data UNIVERSITY OF KUOPIO Finland EU contribution No data Address Savilahdentie 9 1627 KUOPIO See on map Links Website Opens in new window Total cost No data THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution No data Address Old College, South Bridge EDINBURGH See on map Links Website Opens in new window Total cost No data UNIVERSITY OF TORINO Italy EU contribution No data Address Via Verdi 8 TORINO See on map Links Website Opens in new window Total cost No data
