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STANDARDISATION OF HIV NEUTRALISATION ASSAYS TO BE USED IN VACCINE RESEARCH AND CLINICAL TRIALS

Objective

The efficacy of viral vaccines can be confirmed by large sero-epidemiological studies where occurrence of a certain type(s) of functional antibody correlates with protection. In general, antibodies with virus neutralising function are the best correlates o f protection. Following this line of reasoning it is essential that the capacity of candidate HIV vaccines is tested for induction of functional (=neutralizing) antibodies, even if the role of neutralising antibodies in HIV infection and disease remains to be elucidated. Numerous in vitro neutralisation assays have been developed, each one with different variables and endpoints. NeutNet, a group of 13 participants from all over the world, proposes to co-ordinate activities aimed at standardising methods for the measurements of neutralising antibodies to HIV-1 for use in human clinical trials of candidate AIDS vaccines. NeutNet will organize these studies in several steps. First, an initial study will take place with all known neutralisation methods and a pan el of well-characterised and common reagents. The aim is to define appropriate assay(s) and reference controls for neutralisation assays. Second, on the basis of results obtained in the first study, a subsequent study will be performed with polyclonal ser ologic reagents. The aim is to gain understanding of the prerequisites of accurate and reproducible measurement of HIV-1 functional antibodies for HIV vaccine studies. A workshop jointly organized with WHO/UNAIDS will serve to discuss the results of the Ne utNet actions together with a larger body of workers in the field. The information thus obtained will be shared at a global level. The results of NeutNet will benefit HIV vaccine research and clinical trials making it possible to compare all vaccine effort s throughout Europe and beyond.

Call for proposal

FP6-2003-LIFESCIHEALTH-3
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Address
Via Olgettina 60
Milan
Italy

Participants (11)

DUKE UNIVERSITY MEDICAL CENTER
United States
Address
Sorf Bldg., Lasalle St. Ext.
Durham
FUNDACAO OSWALDO CRUZ
Brazil
Address
Av Brasil 4365
Rio De Janeiro, Rj
LUNDS UNIVERSITET
Sweden
Address
Paradisgatan 5 C
Lund
NATIONAL BIOLOGICALS STANDARD BOARD
United Kingdom
Address
Blanche Lane, South Mimms
Potters Bar, Herts
NATIONAL HIV REPOSITORY AND BIOINFORMATIC CENTER (THAILAND)
Thailand
Address
2 Prannok Road; Microbiology Building
Bangkok
NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES
South Africa
Address
1 Modderfontein Road
Sandringham, Johannesburg
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
United States
Address
550 First Avenue
New York
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
PO Box 9600 Oxford
THE HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
United States
Address
13 Taft Court,
Rockville, Md
UNIVERSITY LOUIS PASTEUR, STRASBOURG I
France
Address
4, Rue Blaise Pascal
Strasbourg
VIROLOGIC, INC
United States
Address
345 Oyster Point Blvd
South San Francisco