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Developing Molecular Medicines for Cancer in the Post-Genome Era

Objetivo

Cancer is a European public health problem of overwhelming human and economic significance. There is now unimproved molecular understanding of the key genetic, biochemical and cellular changes leading to cancer, insignificant part due to the efforts of diverse groups of world-class EU-based scientists. With the completion of the human genome sequence imminent, it is now timely to initiate a major European co-ordinated effort to translate fundamental scientific knowledge about cancer into safer, more effective therapies and improved early diagnosticprocedures. The cellular immortality enzyme telemetries (one of the most promising universal cancer markers) and associatedtelomere maintenance mechanisms represent novel anti-cancer targets of enormous therapeutic and diagnostic potential. In MOL CANCER MED, we have established a multinational EU transactional cancer research consortium, in which talented cancer geneticists and molecular biologists will interact with prominent haematologists, clinicians and pathologists to develop these exciting new cellular targets into measurable pre-clinical advances, within a 3.5-year time-frame.

The Project has been structured into three, highly interactive Areas of Activity, involving the fundamental evaluation and pre-clinical validation of:
(i) TELOMERASE as a target for cancer treatment and diagnosis based on new molecular knowledge about its expression and function,
(ii) associated DOWNSTREAM TELOMERE MAINTENANCEMECHANISMS as additional targets for novel drug design, and
(iii) new ANTICANCER DRUGS based on these targets. The Consortium will bring to bear diverse and complementary technological know-how of considerable power to deliver the above primary objectives. Effective management will maximize synergies across MOL CANCERMED in order to produce genuine improvements in the design of new treatments that promise to be active against abroad spectrum of common human malignancies.

Convocatoria de propuestas

FP6-2002-LIFESCIHEALTH
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Régimen de financiación

IP - Integrated Project

Coordinador

BRUNEL UNIVERSITY
Aportación de la UE
Sin datos
Dirección
Kingston Lane
UXBRIDGE
Reino Unido

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Enlaces
Coste total
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Participantes (14)