Objectif Heart failure caused by the ischaemic heart disease is one of the most common causes of morbidity an mortality across Europe, especially high among elderly people, but the post-infarction myocardial injury is also major cause of disability in younger survi vors from myocardial infarction. The proposed project is dedicated to stimulate "state-of-the-art" research on the clinical applications of autologous stem cells, including bone marrow derived stem cells as well as myoblasts, to the regeneration of heart m uscle in irreversibly damaged post- infarction regions. The consortium includes most experienced European clinical researchers in the field, which already had accomplished the phase I clinical trials in participating centres. The researchers from participa ting centres have agreed to coordinate their future clinical trials on stem cell transplantation for myocardial regeneration in patients with postinfarction heart failure, as a result of the proposed project. This will include analysis of polled clinical d ata obtained in participating centres, reciprocal exchange of information on cell culture and cell preparation for transplantation. This will also include standardization of clinical protocols aiming at evaluation of the clinical efficacy of myocardial rep lacement therapy as well as hand-on training of different techniques of cell delivery, including percutaneous cell transplantations, in particular trans-coronary arteries bone marrow stem cell delivery protocols as well as trans- ventricular and trans-card iac-veins myoblast injection techniques. As a result of further integration of the consortium, it is expected to stimulate formation of a common future phase III studies at international level, especially with an option of submitting future Integrated Proj ect application within the 6th Framework Programme. Champ scientifique social sciencessociologydemographymortalitymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinecardiologymedical and health sciencesclinical medicinetransplantation Mots‑clés Stem cells cell therapy organ regeneration Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) LSH-2003-2.1.0-2 - Coordination of clinical trials in Europe LSH-2003-3-3 - Promotion of cooperation with Associated Candidate Countries Appel à propositions FP6-2003-LIFESCIHEALTH-I Voir d’autres projets de cet appel Régime de financement SSA - Specific Support Action Coordinateur UNIVERSITY SCHOOL OF MEDICAL SCIENCES Contribution de l’UE Aucune donnée Adresse Ui. fredry 10 Poznan Pologne Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (8) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire HOPITAL EUROPEEN GEORGES POMPIDOU France Contribution de l’UE Aucune donnée Adresse 20, rue leblanc Paris Voir sur la carte Coût total Aucune donnée UNIVERSITY OF VALLADOLLID Espagne Contribution de l’UE Aucune donnée Adresse Ramon y cajal 3 Valladolid Voir sur la carte Coût total Aucune donnée UNIVERSITY OF ROSTOCK Allemagne Contribution de l’UE Aucune donnée Adresse Schilligallee 35 Rostock Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée CHARLES UNIVERSITY PRAGUE Tchéquie Contribution de l’UE Aucune donnée Adresse Ruska 87 Prague Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITY HOSPITAL, CLERMONT-FERRAND France Contribution de l’UE Aucune donnée Adresse Rue montalembert Clermont-ferrand Voir sur la carte Coût total Aucune donnée VILNIUS UNIVERSITY Lituanie Contribution de l’UE Aucune donnée Adresse Santariskiu str. 2 Vilnius Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée POLISH ACADEMY OF SCIENCES Pologne Contribution de l’UE Aucune donnée Adresse Strzeszynska 32 Poznan Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée ERASMUS UNIVERSITY ROTTERDAM Pays-Bas Contribution de l’UE Aucune donnée Adresse Drmolewaterplein 40 Rotterdam Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée