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Molecular mechanisms of neuronal degeneration: from cell biology to the clinic

Molecular mechanisms of neuronal degeneration: from cell biology to the clinic

Objective

Our objective is to create within the Community the ditions for emergence of novel therapeutic approaches to neurodegenerative disease and neurotrauma, which represent an urgent socio-eomic and human need. The NeuroNE sortium (22 academic groups, 6 SMEs and 1 management partner in 9 different countries) will take a multi-disciplinary (functional genomics and proteomics, physiology, chemistry, clinical studies) and multi-faceted (disease mechanisms, biology of cell death and survival, regeneration mechanisms, high-throughput screening, gene- and cell-based therapies) approach to this problem. Among the neurodegenerative diseases, we will focus on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Spinal cord injury (SCI) will be the main model for neurotrauma. NeuroNE brings together investigators from different backgrounds (basic scientists, active clinicians and therapeutically-oriented SMEs) to work at all levels on a given disease: post-genomic science, molecular and cell biology, animal models, therapeutic strategies and clinical studies. Professional project management will provide efficient integration, realization of scientific objectives and knowledge management. Common infrastructures include shared NeuroNE-funded core facilities in 7 centres, while our web-based database will serve as a European depository for biological research tools. Training will be provided at several levels: by a competitive program of multi-centre postdoctoral fellowships, by mobility of NeuroNE scientists to other centres and platforms, and by the organization of summer schools and laboratory open days. To feed back the benefits of integration into EU society, we have involved patient organizations from the start, identified associated research groups who will benefit immediately from our infrastructures, and opened network meetings to identified scientists from emerging research centres.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Address

The Old Schools, Tinity Lane
Cambridge

United Kingdom

Administrative Contact

James FAWCETT (Professor)

Participants (27)

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SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE

Switzerland

RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG

Germany

UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST UNIVERSITÄT GÖTTINGEN - STIFTUNG OFFENTLICHEN RECHTS

Germany

LUNDS UNIVERSITET

Sweden

NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH

Switzerland

UNIVERSITÀ DEGLI STUDI DI MILANO

Italy

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY

Israel

COMMISSARIAT À L'ENERGIE ATOMIQUE

France

UNIVERSITÄT MUENCHEN

Germany

KAROLINSKA INSTITUTET

Sweden

UNIVERSITÉ DE GENÈVE

Switzerland

MAX-PLANCK-SOCIETY FOR THE ADVANCEMENT OF SCIENCE REPRESENTED BY THE MAX-PLANCK-LNSTITUTE OF NEUROBIOLOGY

Germany

UNIVERSITAETSKLINIKUM ULM

Germany

KINGS COLLEGE LONDON

United Kingdom

FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW

Belgium

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Spain

UNIVERSITÄT ZÜRICH

Switzerland

UNIVERSITY OF TURIN DEPT OF NEUROSCIENCE

Italy

TROPHOS SA

France

GENETRIX S.L

Spain

PHARMAXON

France

MILTENYI BIOTEC GMBH; MACS MOLECULAR BUSINESS UNIT

Germany

CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE

France

ISTITUTO VENETO DI MEDICINA MOLECOLARE

Italy

D-PHARM LTD

Israel

THE BABRAHAM INSTITUTE

United Kingdom

INSERM-TRANSFERT SA

France

Project information

Grant agreement ID: 512039

  • Start date

    1 January 2005

  • End date

    30 June 2009

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 20 499 574

  • EU contribution

    € 8 300 000

Coordinated by:

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

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