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Molecular mechanisms of neuronal degeneration: from cell biology to the clinic

Objective

Our objective is to create within the Community the ditions for emergence of novel therapeutic approaches to neurodegenerative disease and neurotrauma, which represent an urgent socio-eomic and human need. The NeuroNE sortium (22 academic groups, 6 SMEs and 1 management partner in 9 different countries) will take a multi-disciplinary (functional genomics and proteomics, physiology, chemistry, clinical studies) and multi-faceted (disease mechanisms, biology of cell death and survival, regeneration mechanisms, high-throughput screening, gene- and cell-based therapies) approach to this problem. Among the neurodegenerative diseases, we will focus on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Spinal cord injury (SCI) will be the main model for neurotrauma. NeuroNE brings together investigators from different backgrounds (basic scientists, active clinicians and therapeutically-oriented SMEs) to work at all levels on a given disease: post-genomic science, molecular and cell biology, animal models, therapeutic strategies and clinical studies. Professional project management will provide efficient integration, realization of scientific objectives and knowledge management. Common infrastructures include shared NeuroNE-funded core facilities in 7 centres, while our web-based database will serve as a European depository for biological research tools. Training will be provided at several levels: by a competitive program of multi-centre postdoctoral fellowships, by mobility of NeuroNE scientists to other centres and platforms, and by the organization of summer schools and laboratory open days. To feed back the benefits of integration into EU society, we have involved patient organizations from the start, identified associated research groups who will benefit immediately from our infrastructures, and opened network meetings to identified scientists from emerging research centres.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

NoE - Network of Excellence

Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Address
The Old Schools, Tinity Lane
Cambridge
United Kingdom

Participants (27)

SWISS FEDERAL INSTITUTE OF TECHNOLOGY LAUSANNE
Switzerland
Address
Sg-aab132
Lausanne
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Germany
Address
Seminarstr. 2
Heidelberg
UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST UNIVERSITÄT GÖTTINGEN - STIFTUNG OFFENTLICHEN RECHTS
Germany
Address
Robert-koch Strasse 40
Goettingen
LUNDS UNIVERSITET
Sweden
Address
Bmc A10
117 Lund
NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
Switzerland
Address
Maulbeerstrasse 66
Basel
UNIVERSITÀ DEGLI STUDI DI MILANO
Italy
Address
Via Balzaretti 9
Milano
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
Address
Technion City
Haifa
COMMISSARIAT À L'ENERGIE ATOMIQUE
France
Address
31-33, Rue De La Fédération
Paris
UNIVERSITÄT MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
Muenchen
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Vag 13
Stockholm
UNIVERSITÉ DE GENÈVE
Switzerland
Address
1211 Geneve
Geneva 4
MAX-PLANCK-SOCIETY FOR THE ADVANCEMENT OF SCIENCE REPRESENTED BY THE MAX-PLANCK-LNSTITUTE OF NEUROBIOLOGY
Germany
Address
Am Klopferspitz 18A
Martinsried
UNIVERSITAETSKLINIKUM ULM
Germany
Address
Albert-einstein-allee 29
Ulm
KINGS COLLEGE LONDON
United Kingdom
Address
Strand
London
FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW
Belgium
Address
Rijvisschestraat 120
Zwijnaarde
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Address
Serrano 117
Madrid
UNIVERSITÄT ZÜRICH
Switzerland
Address
Raemistrasse 71
Zurich
UNIVERSITY OF TURIN DEPT OF NEUROSCIENCE
Italy
Address
Via Verdi 8
Torino
TROPHOS SA
France
Address
Parc Scientifique De Luminy - Luminy Biotech Entreprises
Case 931 Marseille
GENETRIX S.L
Spain
Address
Parque Tecnologico De Madrid
Madrid
PHARMAXON
France
Address
Ibdm-nmda-campus De Luminy-case 907
Marseille
MILTENYI BIOTEC GMBH; MACS MOLECULAR BUSINESS UNIT
Germany
Address
Stöckheimer Weg 1
Cologne
CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange, 3
Paris
ISTITUTO VENETO DI MEDICINA MOLECOLARE
Italy
Address
Via Orus, 2
Padova
D-PHARM LTD
Israel
Address
Kiryat Weizmann Science Park, Bldg.7
2313 Rehovot
THE BABRAHAM INSTITUTE
United Kingdom
Address
Babraham Research Campus
Cambridge
INSERM-TRANSFERT SA
France
Address
101 Rue De Tolbiac
Paris