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The control of embryo implantation: studies of gene expression, protein profiles / functions at the utero embryonic level: cellular and molecular developmental events at the feto maternal interface

Project information

Grant agreement ID: 512040

  • Start date

    1 October 2004

  • End date

    30 September 2008

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 23 400 000

  • EU contribution

    € 7 400 000

Coordinated by:

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France

Objective

EMBIC virtual European laboratory on major mechanisms of implantation will study thoroughly the main cellular - cytokine networks/ key pathways promoting the de novo development of the decidua basalis and the mature placenta. Present fragmentation of experimental capacity and disparate approaches result in lack of a comprehensive skills base, and of access to specialised approaches/ technological platforms such as strict animal experimentation, genomics and proteomics facilities or multicentric clinical evaluation. Which need coordinated approach. We will thus: 1. Assemble critical talents and approaches, to Integrate EMBIC laboratories via the joint programme of activities: 1.1. Early embryo signalling to ultimately allow selection of only those embryos which will effectively implant; 1.2. Key events in tissue remodelling: 1.3. Homing/ proper activation of Natural Killer (NK) cells 1.4. Role of MHC class I gene products and their recognition by NK cells 1.5. Control of the inflammation complement related pathways 1.6. Cytokine/ chemokines/ profiling 1.7. Invasion and early post implantation events, Matrix Metallo Protease based proteolysis/ adhesion molecule functions. 2. Constitute a European cohort of infertile women and RT generated DNA, sera and micro-biopsy tissue samples banks. 3. Establish guidelines for management of infertile women combined with diagnosis procedures and ultimately recombinant technologies therapies for selected pathologies. 4. Open the network for education and cooperative experimentation. EMBIC will contribute and benefit from the creation of integrated platforms based on animal models, genomic and proteomic facilities, protein intra-net database set-up, integrated clinical set-up, and will spread excellence by facilitating the exchange of scientists within the laboratories, promote recruitment/training of out network post-docs, organise workshops and satellite meetings and an annual summer school.

Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

Address

101 Rue De Tolbiac
Paris

France

Participants (22)

CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

UNIVERSIDAD AUTONOMA DE BARCELONA

Spain

UNIVERSITY OF ROME "LA SAPIENZA"

Italy

UNIVERSITY OF RIJEKA

Croatia

UNIVERSITY OF TRIESTE

Italy

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

CHARITÉ, UNIVERSITY MEDICINE BERLIN.

Germany

FRIEDRICH-SCHILLER-UNIVERSITÄT JENA

Germany

CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE

France

UNIVERSITY OF LEICESTER

United Kingdom

UNIVERSITY OF FLORENCE

Italy

UNIVERSITÉ DE LIÈGE

Belgium

PECS UNIVERSITY MEDICAL SCHOOL

Hungary

MEDICAL UNIVERSITY OF GRAZ

Austria

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

INSERM-TRANSFERT SA

France

UNVERSITY OF VERSAILLE SAINT QUENTIN EN YVELINES

France

HUMANITAS MIRASOLE SPA

Italy

NATIONAL UNIVERSITY OF IREMAND, DUBLIN/UNIVERSITY COLLEGE DUBLIN

Ireland

HELENA VENIZELOU MATERNITY HOSPITAL

Greece

MITHRA SA

Belgium

UNIVERSITY OF EDINBURGH

United Kingdom

Project information

Grant agreement ID: 512040

  • Start date

    1 October 2004

  • End date

    30 September 2008

Funded under:

FP6-LIFESCIHEALTH

  • Overall budget:

    € 23 400 000

  • EU contribution

    € 7 400 000

Coordinated by:

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France