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The control of embryo implantation: studies of gene expression, protein profiles / functions at the utero embryonic level: cellular and molecular developmental events at the feto maternal interface

Objective

EMBIC virtual European laboratory on major mechanisms of implantation will study thoroughly the main cellular - cytokine networks/ key pathways promoting the de novo development of the decidua basalis and the mature placenta. Present fragmentation of experimental capacity and disparate approaches result in lack of a comprehensive skills base, and of access to specialised approaches/ technological platforms such as strict animal experimentation, genomics and proteomics facilities or multicentric clinical evaluation. Which need coordinated approach. We will thus: 1. Assemble critical talents and approaches, to Integrate EMBIC laboratories via the joint programme of activities: 1.1. Early embryo signalling to ultimately allow selection of only those embryos which will effectively implant; 1.2. Key events in tissue remodelling: 1.3. Homing/ proper activation of Natural Killer (NK) cells 1.4. Role of MHC class I gene products and their recognition by NK cells 1.5. Control of the inflammation complement related pathways 1.6. Cytokine/ chemokines/ profiling 1.7. Invasion and early post implantation events, Matrix Metallo Protease based proteolysis/ adhesion molecule functions. 2. Constitute a European cohort of infertile women and RT generated DNA, sera and micro-biopsy tissue samples banks. 3. Establish guidelines for management of infertile women combined with diagnosis procedures and ultimately recombinant technologies therapies for selected pathologies. 4. Open the network for education and cooperative experimentation. EMBIC will contribute and benefit from the creation of integrated platforms based on animal models, genomic and proteomic facilities, protein intra-net database set-up, integrated clinical set-up, and will spread excellence by facilitating the exchange of scientists within the laboratories, promote recruitment/training of out network post-docs, organise workshops and satellite meetings and an annual summer school.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/clinical medicine/embryology
  • /medical and health sciences/clinical medicine/obstetrics and gynaecology/obstetrics

Call for proposal

FP6-2003-LIFESCIHEALTH-I
See other projects for this call

Funding Scheme

NoE - Network of Excellence

Coordinator

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
Address
101 Rue De Tolbiac
Paris
France

Participants (22)

CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
Address
Campus De La Universidad Autonoma De Barcelona
Bellaterra Cerdanyola Del Vallès)
UNIVERSITY OF ROME "LA SAPIENZA"
Italy
Address
Viale Regina Elena, 324
Rome
UNIVERSITY OF RIJEKA
Croatia
Address
B. Branchetta 20
Rijeka
UNIVERSITY OF TRIESTE
Italy
Address
Piazzale Europa, 1
Trieste
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
Address
Via Eritrea 62
Milan
CHARITÉ, UNIVERSITY MEDICINE BERLIN.
Germany
Address
Schumannstr. 20-21
Berlin
FRIEDRICH-SCHILLER-UNIVERSITÄT JENA
Germany
Address
Bachstrasse 18
Jena
CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE
France
Address
3, Rue Michel Ange
Paris
UNIVERSITY OF LEICESTER
United Kingdom
Address
University Road
Leicester
UNIVERSITY OF FLORENCE
Italy
Address
Viale Morgagni 85
Florence
UNIVERSITÉ DE LIÈGE
Belgium
Address
Place Du 20 Août
Liège
PECS UNIVERSITY MEDICAL SCHOOL
Hungary
Address
12Sziegeti Str
Pecs
MEDICAL UNIVERSITY OF GRAZ
Austria
Address
Auenbruggerplatz 2
Graz
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
147 Rue De L'université
Paris
INSERM-TRANSFERT SA
France
Address
101 Rue De Tolbiac
Paris
UNVERSITY OF VERSAILLE SAINT QUENTIN EN YVELINES
France
Address

Saint Quentin En Yvelines
HUMANITAS MIRASOLE SPA
Italy
Address
Via Manzoni, 56
Rozzano - Milano
NATIONAL UNIVERSITY OF IREMAND, DUBLIN/UNIVERSITY COLLEGE DUBLIN
Ireland
Address
Belfield
Dublin 4
HELENA VENIZELOU MATERNITY HOSPITAL
Greece
Address
2 Helena Venizelou Sq
Athens
MITHRA SA
Belgium
Address
1 Rue Des Foulons
Liege
UNIVERSITY OF EDINBURGH
United Kingdom
Address
Old College, South Bridge
Edinburgh