Cel In this STREP we intend to use cutting-edge nuclear magnetic resonance (NMR) techniques to develop a fast, integrated approach to support structure-based drug design. The project will speed up drug design efforts for typical drug targets and will shorten t he lead-time for new drugs. We will develop fast, reliable and robust NMR techniques for exact structural and dynamic characterization of drug-receptor interactions at atomic resolution, thus enabling and/or improving the potential for directed development of drugs exhibiting a maximum of desired interaction characteristics in a relatively short time. Protocols for obtaining the NMR data needed for the characterization of proteins, inhibitors and protein-inhibitor complexes will be developed, starting from known X-ray structures, thus establishing a tight connection between NMR and X-ray technology and exploiting optimally the complementary strengths of both techniques. The new NMR technologies will be complemented by computer modelling for protein-inhibito r complexes and by advanced tailored protein expression methods. In order to show the impact for drug development, the new approach will aim at phosphatases, a major class of drug targets with broad medical implications. A majority of cellular functions d epend on phosphorylation by kinases and de-phosphorylation by phosphatases. High eukaryotes encode approximately 500 kinase and 100 phosphatase schemes, corresponding to 3% of the genome. While the importance of kinases in cellular regulation led to substa ntial drug design activities, the importance of phosphatases has only been appreciated recently. Phosphatases regulate insulin signalling, cell growth and the cell cycle. Therefore, the inhibition of phosphatases is perused for the treatment of diabetes, o besity and various cancers. Human genome data provide access to a broad range of phosphatases, allowing systematic drug design using advanced techniques to identify potential inhibitors. Dziedzina nauki medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesclinical medicinepneumologytuberculosis Słowa kluczowe Drug design NMR Spectroscopy Phosphatases Structural genomics Program(-y) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Temat(-y) LSH-2003-1.1.0-1 - Topics for Specific Targeted Research Project in the area of Fundamental knowledge and basic tools for functional genomics in all organisms Zaproszenie do składania wniosków FP6-2003-LIFESCIHEALTH-I Zobacz inne projekty w ramach tego zaproszenia System finansowania STIP - Specific Targeted Innovation Project Koordynator UTRECHT UNIVERSITY, FACULTY OF CHEMISTRY, BIJVOET CENTER FOR BIOMOLECULAR RESEARCH, Wkład UE Brak danych Adres Heidelberglaan 8 UTRECHT Niderlandy Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (5) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko JOHANN WOLFGANG GOETHE-UNIVERSITY Niemcy Wkład UE Brak danych Adres Senckenberganlage 31 FRANKFURT/ MAIN Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLPROTEINE PARAMAGNETICHE Włochy Wkład UE Brak danych Adres Via Luigi Sacconi, 6 SESTO FIORENTINO Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL Zjednoczone Królestwo Wkład UE Brak danych Adres 123 Old Brompton Road LONDON Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych SYNTHACON GMBH Niemcy Wkład UE Brak danych Adres Am Haupttor - Gebäude 4310 LEUNA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych MEDIZINISCHE UNIVERSITÄT WIEN (MEDICAL UNIVERSITY VIENNA) Austria Wkład UE Brak danych Adres Spitalgasse 23 VIENNA Zobacz na mapie Linki Strona internetowa Opens in new window Koszt całkowity Brak danych