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A prospective analysis of the mechanisms of nuclear hormone receptors and their potential as tools for the assessment of developmental toxicity

Objective

In view of developing an innovative non-animal test method for chemicals, medicines, biological and bio-materials, the proposed project has the final goal of producing a prospective analysis of the mechanisms of nuclear hormone receptors and their potential as tools for the assessment of developmental toxicity. The prospective analysis will either define a practical research programme for future RDT activities in this field, or conclude that the area is not sufficiently mature at present time. The specific objectives of the project are the following: - To investigate the role of nuclear hormone receptors in developmental and reproductive biology and to review the state of the science in this field; - To define a practical research programme with the aim of enhancing knowledge on the mechanisms of developmental toxicity and the role of nuclear receptors in the process; - To develop a plan aimed at applying such understanding to the future assessment of the relevance of in vitro systems as predictive models for developmental toxicity. The project, proposed as an SSA, consists of two workshops where the best European research resources in the area of molecular biology, genomics and developmental toxicology will be pooled together with the aim of investigating the role of nuclear hormone receptors in developmental and reproductive biology.

Call for proposal

FP6-2003-LIFESCIHEALTH-I
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Funding Scheme

SSA - Specific Support Action

Coordinator

EXXONMOBIL PETROLEUM & CHEMICAL
Address
Polderdijkweg
Antwerpen
Belgium

Participants (8)

CXR BIOSCIENCES LTD
United Kingdom
Address
James Lindsay Place. Dundee Technopole
Dundee
CHARLES UNIVERSITY PRAGUE, 1ST MEDICAL FACULTY
Czechia
Address
Ovocný Trh 3/5
Prague 1
ARISTOTLE UNIVERSITY OF THESSALONIKI
Greece
Address
University Campus
Thessaloniki
CENTRE FOR MEDICAL BIOLOGY, POLISH ACADEMY OF MEDICINE
Poland
Address
Lodowa 106
Lodz
UNIVERZITA OBRANY - FAKULTA VOJENSKÉHO ZDRAVOTNICTVÍ, HRADEC KRÁLOVÉ
Czechia
Address
Trebesska 1575
Hradec Kralove
MEDICAL RESEARCH CENTER, POLISH ACADEMY OF SCIENCES
Poland
Address
Pawinskiego 5
Warsaw
FRANCIS CARPANINI
United Kingdom
Address
Wiltshire Avenue 33
Crownthorne
NOFER INSTITUTE OF OCCUPATIONAL MEDICINE
Poland
Address
Sw. Teresy 8
199 Lodz