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DNA damage responses, Genomic instability and Radiation-Induced Cancer: The problem of risk at low and protracted doses (RISC-RAD)

Project information

Grant agreement ID: 508842

  • Start date

    1 January 2004

  • End date

    31 October 2008

Funded under:

FP6-EURATOM-RADPROT

  • Overall budget:

    € 15 331 305

  • EU contribution

    € 10 000 000

Coordinated by:

COMMISSARIAT A L'ENERGIE ATOMIQUE

France

Objective

Radiation protection requires a thorough understanding of low dose ionising radiation. Currently extrapolation from high doses is necessary to estimate the effects of low doses. Furthermore, it is critically important to have an appreciation of the variation in individual responses to radiation among the human population. Present estimates of the risks from radiation exposure are based largely on the "average" individual in an exposed population. However, clinical observations of adverse reactions to radiotherapy indicate large variations in individual radiosensitivity. Quantification of risk requires the identification of new parameters taking into account these differences in radiation responses. Therefore, a detailed knowledge of the mechanisms by which radiation induces cancer is essential. In this project, leading European research teams join forces to understand the various steps involved in the multistage process of radiation-induced tumourigenesis through detailed analysis of DNA damage responses (repair, checkpoints, apoptosis), genomic instability as well as mechanisms/genetics and modelling of radiation tumourigenesis. The research in this project will answer the following specific questions: (i) Who is at risk? (ii) When do the factors modifying risk exert their influence? (iii) What are the mechanisms through which risk factors act? (iv) Is there a link between radiosensitivity of individuals (short term) and susceptibility to cancer (Late after exposure)? The consortium will apply innovative and state of the art technology (genomics, proteomics, advanced fluorescence microscopy, RNA interference, gene knock-in technology). We stress that the identification of genetic variables in the processing of radiation induced DNA damage is vital for re-evaluation of current radio-protective measures and the development of future protective procedures.

Coordinator

COMMISSARIAT A L'ENERGIE ATOMIQUE

Address

France

Participants (33)

LEIDEN UNIVERSITY MEDICAL CENTER

Netherlands

NATIONAL RADIOLOGICAL PROTECTION BOARD

United Kingdom

GSF- FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH

Germany

SATEILYTURVAKESKUS - RADIATION AND NUCLEAR SAFETY AUTHORITY

Finland

ERASMUS MEDICAL CENTER ROTTERDAM

Netherlands

UNIVERSITY OF SUSSEX

United Kingdom

MEDICAL RESEARCH COUNCIL

United Kingdom

STOCKHOLM UNIVERSITET

Sweden

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

ECOLE NORMALE SUPERIEURE DE LYON

France

CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS

Spain

UNIVERSIDAD AUTONOMA DE BARCELONA

Spain

UNIVERSITA DEGLI STUDI DI PAVIA

Italy

BRUNEL UNIVERSITY

United Kingdom

AARHUS UNIVERSITET - UNIVERSITY OF AARHUS

Denmark

ENTE PER LE NUOVE TECNOLOGIE, L' ENERGIA E L'AMBIENTE

Italy

NUCLEAR RESEARCH AND CONSULTANCY GROUP

Netherlands

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

NATIONAL UNIVERSITY OF IRELAND - GALWAY

Ireland

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

ASSOCIATION POUR LE DEVELOPPEMENT DE LA PHYSIQUE ATOMIQUE

France

UNIVERSIDAD AUTONOMA DE MADRID

Spain

UNIVERSITAET SALZBURG

Austria

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

United Kingdom

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

GRAY LABORATORY CANCER RESEARCH TRUST

United Kingdom

SYDDANSK UNIVERSITET

Denmark

HEALTH PROTECTION AGENCY, CENTRE FOR RADIATION, CHEMICAL AND ENVIRONMENTAL HAZARDS - RADIATION PROTECTION DIVISION

United Kingdom

UNIVERSITÄTSKLINIKUM FREIBURG ON BEHALF OF THE ALBERT-LUDWIG-UNIVERSITY FREIBURG

Germany

FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECULARE

Italy

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI tumourI

Italy

Project information

Grant agreement ID: 508842

  • Start date

    1 January 2004

  • End date

    31 October 2008

Funded under:

FP6-EURATOM-RADPROT

  • Overall budget:

    € 15 331 305

  • EU contribution

    € 10 000 000

Coordinated by:

COMMISSARIAT A L'ENERGIE ATOMIQUE

France