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Development of an SPR-based biosensor for the detection of lipophilic phycotoxins in shellfish residues

Development of an SPR-based biosensor for the detection of lipophilic phycotoxins in shellfish residues

Objective

Lipophilic phycotoxins are often found in high levels in bivalve molluscs, echinoderms, tunicates ormarine gastropods and the consumption of these contaminated seafoods can pose a significant threatto human health. There is a need to monitor levels of these toxins in seafood meant for humanconsumption and to keep levels below defined thresholds. In Europe the broad spectrum mouse or ratbioassay is the only official method for the detection of these toxins, although recently directives wereapproved stating that any functional method could be used to replace the bioassay if fully validated.
The overall objective of this project is to develop a multi-channel, high-throughput biosensor for the detection of diarrheic shellfish toxins, yessotoxins, pectenotoxins, azaspiracids and gymnodimine. Theproposed biosensor will exploit the phenomenon of Surface Plasmon Resonance (SPR) to detect andmeasure these lipophilic phycotoxins in seafood residues. The sensor will be designed as an inhibitionassay capable of rapid, reliable multi-toxin detection. The technology allows real-time, automated,multiresidue analysis of food products, both in laboratories and at on-site locations and is capable ofmeasuring coloured, turbid or opaque sample solutions. The assembled consortium has a great dealof experience in their respective fields and demonstrates a high level of complementarity. The projecthas the required expertise and resources required to carry out the development of this valuable newtechnology, which has the potential not only to eliminate the need for the ethically concerningbioassays currently used, but also to provide a simple, cheap and improved method for the detectionof phycotoxins in shellfish residues.

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Coordinator

UNIVERSIDADE SANTIAGO DE COMPOSTELA

Address

Plaza Do Obradoiro
Santiago De Compostela

Spain

Administrative Contact

Luis BOTANA (Dr)

Participants (8)

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CHALEX RESEARCH LTD.

United Kingdom

QUEEN'S UNIVERSITY BELFAST'

United Kingdom

ANFACO

Spain

EUROPEAN COMMUNITY REFERENCE LABORATORY ON MARINE BIOTOXINS

Spain

XENOSENSE LTD.

United Kingdom

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

EGE UNIVERSITY

Turkey

INSTITUTE OF FOOD HYGIENE OF THESSALONIKI

Greece

Project information

Grant agreement ID: 514055

  • Start date

    1 January 2005

  • End date

    30 June 2008

Funded under:

FP6-FOOD

  • Overall budget:

    € 1 149 743

  • EU contribution

    € 802 847

Coordinated by:

UNIVERSIDADE SANTIAGO DE COMPOSTELA

Spain