The proposed multi-disciplinary project will focus on the development, validation, and standardisation ofreference methods (LC-MS) and cost-effective assays for the identification and quantification of lipophilic marinebiotoxins, which have been included in the European legislation, and for which currently no methods exist.Existing knowledge on functional and biochemical assays will be used. Application of the Biacore SPR biosensortechnology will be applied to establish high throughput analyses. The new methods should lead to replacementof the existing animal tests. A validation study of the developed tests and a feasibility study on the production ofCRMs will be carried out according to international validation protocols. Early warning systems, based on geneexpression and passive samplers will be developed. The second part of this project will focus on measurementsto be taken after the outbreak of a harmful algal bloom, including improvement of decontamination techniquesand implementation of traceability systems. A report on the harmonisation of monitoring, control, traceability, andhandling of shellfish in EU member states will be prepared. An expert panel will guide and help to avoid overlapwith work elsewhere. Links with other EU projects (SHELLFISH, SEAFOODplus and BioCop) will be establishedto strengthen research. Contacts with the CEN and the IRMM (Joint Research Centre) will be established toobtain advice on standardisation and CRM production. The following key deliverables will be produced: assaysfor all lipophilic toxins included in European Directives, SPR technology for high throughput analysis; a referencemethod; an early warning system based on gene expression and/or passive sampling; recommendations on thecertification of reference materials; improved decontamination procedures; report on the harmonisation ofmonitoring, control and handling contaminated shellfish; workshop and training; newsletters...
Call for proposal
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Funding SchemeSTIP - Specific Targeted Innovation Project