CORDIS
EU research results

CORDIS

English EN
Environmental risk assessment of pharmaceuticals

Environmental risk assessment of pharmaceuticals

Objective

The overall objective of ERAPharm is to improve and complement existing knowledge and procedures for theenvironmental risk assessment (ERA) of human and veterinary pharmaceuticals. Based on EU regulatoryframeworks on the ERA of pharmaceuticals and on the outcome of previous projects ERAPharm will address thefollowing aspects:It will investigate previously unstudied major routes leading to exposure of the terrestrial and aquaticenvironment and subsequent fate of pharmaceuticals in surface water and sediment. Factors and processesaffecting the behavior of pharmaceuticals in the environment will be studied on the laboratory, semi-field and fieldscale. A scenario-based exposure assessment system will be developed for predicting concentrations of pharmaceuticals in soils, surface waters and sediments and leaching to groundwater. It will be investigated if environmentally relevant concentrations of pharmaceuticals pose a risk to aquatic and terrestrial organisms. Pharmaceuticals and selected transformation products will be screened using in vitro and low complexity bioanalytical tests in order to provide a first hazard characterization and to target higher tier testing. Higher tier test methods will be improved and applied for detecting the effects of long-term, low-levelexposure to pharmaceuticals on aquatic and terrestrial invertebrates and fish. It will be evaluated if information on pharmaco- and toxicodynamics in mammalian species can be used to predict effects of pharmaceuticals on environmental organisms. Moreover, the effects of antibiotics on microbial communities will be studied with a main focus on the spread of genetically encoded resistance. Based on the developed approaches recommendations will be provided on how to improve the ERA proceduresfor pharmaceuticals. A guidance document will be compiled that will be made available to regulators, industry andthe scientific community.

Coordinator

ECT OEKOTOCXIKOLOGIE GMBH

Address

BottgerstraSSE, 2-14
D-65439 FlÖRsheim

Germany

Administrative Contact

Thomas KNACKER (Dr)

Participants (15)

Sort alphabetically

Expand all

AARHUS UNIVERSITET

Denmark

ASTRAZENECA UK LTD

United Kingdom

BRUNEL UNIVERSITY

United Kingdom

BUNDESANSTALT FUER GEWAESSERKUNDE

Germany

CANADIAN WATER NETWORK

Canada

CENTRE NATIONAL DU MACHINISME AGRICOLE, DU GENIE RURAL, DES EAUX ET DES FORETS

France

DANMARKS FARMACEUTISKE UNIVERSITET

Denmark

DANMARKS MILJOEUNDERSOEGELSER

Denmark

EAWAG - EIDGENOESSISCHE ANSTALT FUR WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ

Switzerland

GEOTECHNISCHES INSTITUT AG

Switzerland

INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA

Spain

KOBENHAVNS UNIVERSITET

Denmark

UMWELTBUNDESAMT

Germany

UNIVERSITEIT UTRECHT

Netherlands

UNIVERSITY OF YORK.

United Kingdom

Project information

Grant agreement ID: 511135

  • Start date

    1 October 2004

  • End date

    30 September 2007

Funded under:

FP6-SUSTDEV

  • Overall budget:

    € 3 710 298

  • EU contribution

    € 2 797 198

Coordinated by:

ECT OEKOTOCXIKOLOGIE GMBH

Germany