Objective The overall objective of ERAPharm is to improve and complement existing knowledge and procedures for theenvironmental risk assessment (ERA) of human and veterinary pharmaceuticals. Based on EU regulatoryframeworks on the ERA of pharmaceuticals and on the outcome of previous projects ERAPharm will address thefollowing aspects:It will investigate previously unstudied major routes leading to exposure of the terrestrial and aquaticenvironment and subsequent fate of pharmaceuticals in surface water and sediment. Factors and processesaffecting the behavior of pharmaceuticals in the environment will be studied on the laboratory, semi-field and fieldscale. A scenario-based exposure assessment system will be developed for predicting concentrations of pharmaceuticals in soils, surface waters and sediments and leaching to groundwater. It will be investigated if environmentally relevant concentrations of pharmaceuticals pose a risk to aquatic and terrestrial organisms. Pharmaceuticals and selected transformation products will be screened using in vitro and low complexity bioanalytical tests in order to provide a first hazard characterization and to target higher tier testing. Higher tier test methods will be improved and applied for detecting the effects of long-term, low-levelexposure to pharmaceuticals on aquatic and terrestrial invertebrates and fish. It will be evaluated if information on pharmaco- and toxicodynamics in mammalian species can be used to predict effects of pharmaceuticals on environmental organisms. Moreover, the effects of antibiotics on microbial communities will be studied with a main focus on the spread of genetically encoded resistance. Based on the developed approaches recommendations will be provided on how to improve the ERA proceduresfor pharmaceuticals. A guidance document will be compiled that will be made available to regulators, industry andthe scientific community. Fields of science natural scienceschemical sciencesanalytical chemistrymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesbotanynatural sciencesbiological scienceszoologyinvertebrate zoology Keywords Pharmaceuticals exposure modelling fate processes long-term effects specific effects targeted testing transformation products Programme(s) FP6-SUSTDEV - Sustainable Development, Global Change and Ecosystems: thematic priority 6 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) SUSTDEV - Sustainable development, global change and ecosystems SUSTDEV-2004-3.VII.1.1.b - Methods for risk assessment of pharmaceuticals in the environment Call for proposal FP6-2003-GLOBAL-2 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator ECT OEKOTOCXIKOLOGIE GMBH EU contribution No data Address Bottgerstraße, 2-14 D-65439 FLÖRSHEIM Germany See on map Links Website Opens in new window Total cost No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all AARHUS UNIVERSITET Denmark EU contribution No data Address Nordre Ringgade 1 AARHUS C See on map Links Website Opens in new window Total cost No data ASTRAZENECA UK LTD United Kingdom EU contribution No data Address Stanhope Gate 15 LONDON See on map Links Website Opens in new window Total cost No data BRUNEL UNIVERSITY United Kingdom EU contribution No data Address Kingston Lane UXBRIDGE See on map Links Website Opens in new window Total cost No data BUNDESANSTALT FUER GEWAESSERKUNDE Germany EU contribution No data Address AM MAINZER TOR 1 KOBLENZ See on map Links Website Opens in new window Total cost No data CANADIAN WATER NETWORK Canada EU contribution No data Address 200 University Avenue West WATERLOO, ONTARIO See on map Links Website Opens in new window Total cost No data CENTRE NATIONAL DU MACHINISME AGRICOLE, DU GENIE RURAL, DES EAUX ET DES FORETS France EU contribution No data Address Parc de Tourvoie ANTONY See on map Links Website Opens in new window Total cost No data DANMARKS FARMACEUTISKE UNIVERSITET Denmark EU contribution No data Address Noerregade 10 KOBENHAVN See on map Links Website Opens in new window Total cost No data DANMARKS MILJOEUNDERSOEGELSER Denmark EU contribution No data Address Frederiksborgvej 399 358 ROSKILDE See on map Links Website Opens in new window Total cost No data EAWAG - EIDGENOESSISCHE ANSTALT FUR WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ Switzerland EU contribution No data Address Ueberlandstrasse 133 DUEBENDORF See on map Links Website Opens in new window Total cost No data GEOTECHNISCHES INSTITUT AG Switzerland EU contribution No data Address Gartenstrasse 13 BERN See on map Links Website Opens in new window Total cost No data INSTITUTO NACIONAL DE INVESTIGACION Y TECNOLOGIA AGRARIA Y ALIMENTARIA Spain EU contribution No data Address Carretera de la Coruna Km7.5 MADRID See on map Links Website Opens in new window Total cost No data KOBENHAVNS UNIVERSITET Denmark EU contribution No data Address Noerregade 10 KOBENHAVN See on map Links Website Opens in new window Total cost No data UMWELTBUNDESAMT Germany EU contribution No data Address Woerlitzer Platz 1 DESSAU See on map Links Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution No data Address Heidelberglaan 8 UTRECHT See on map Links Website Opens in new window Total cost No data UNIVERSITY OF YORK. United Kingdom EU contribution No data Address Heslington YORK See on map Links Website Opens in new window Total cost No data