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Multipurpose Force Tool for Quantitative Nanoscale Analysis and Manipulation of Biomolecular, Polymeric and Heterogeneous Materials

Multipurpose Force Tool for Quantitative Nanoscale Analysis and Manipulation of Biomolecular, Polymeric and Heterogeneous Materials

Objective

FORCETOOL (FT) proposes to develop a multipurpose tool for quantitative nanoscale analysis and manipulation of biomolecular, polymeric and heterogeneous surfaces. Key features of the proposed instrument are 1 nm spatial resolution and 1 pN force se nsitivity; operation in technological relevant environments (air or liquids) and with no impact on the sample surface.The multifunctionality and flexibility of FT will enable characterization, control or manipulation of structures on a nanometer-scale, s o it will open new approaches for manufacturing at molecular and nanoscale levels. This tool is based on two innovative concepts : (i) the bi-modal AFM and (ii) the multimaterial methodolody. The bi-modal AFM concept considers the cantilever as a thre e dimensional object with several resonance modes, in particular two. The concept departs radically from the established principles of dynamic force microscopy (only the fundamental mode is considered). The double excitation allows to separate topogr aphy from composition contributions in the experimental data. Furthermore, the bi-modal AFM is about two orders of magnitude more sensitive to force variations than state of the art tapping mode AFMs. The multimaterial methodology will allow to tran sform the amplitude, frequency or phase shift changes measured by the instrument into quantitative information about the sample properties. The multimaterial methodology has both a general framework to describe dynamic force microscopy interactions an d specific codes to be used with different materials such as inorganic materials, biomolecules , polymers or molecular architectures. Specific key goals are: Topography, composition analysis and manipulation of biomolecules, polymers and hete rogeneous surfaces; operation in air or liquids environments; 1 nm spatial resolution and 1 pN force sensitivity; compatibility with existing atomic force microscopes

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Coordinator

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTFICAS

Address

Serrano 117
Madrid

Spain

Administrative Contact

Ricardo GARCIA (Prof.)

Participants (8)

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CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

UNIVERSITY OF TWENTE

Netherlands

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

CHEMNITZ UNIVERSITY OF TECHNOLOGY

Germany

UNIVERSIDAD AUTONOMA DE MADRID

Spain

NANOWORLD SERVICES GMBH

Germany

UNIVERSITY OF LINZ

Austria

ELDISA S.L.

Spain

Project information

Grant agreement ID: 13684

  • Start date

    1 February 2005

  • End date

    31 January 2008

Funded under:

FP6-NMP

  • Overall budget:

    € 3 135 130

  • EU contribution

    € 2 000 000

Coordinated by:

CONSEJO SUPERIOR DE INVESTIGACIONES CIENTFICAS

Spain