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CellPROM - Cell Programming by Nanoscaled Devices

Objective

We will develop a new generation of nano-biotechnological equipment, the CellPROMs. As the EPROM paved the way to a broad application of microelectronics, CellPROMs will overcome current limits of and revolutionise the existing handling technologies and procedures by automated, compact and parallel yet still individual handling of large numbers of cellular samples.

Typical targets will be animal and human adult stem cells. Human embryonic stem cells will not be used. The main task of our IP is to develop procedures and devices for the precise creation of NanoScapes - individually tailored nanoscaled macromolecular landscapes, which will allow, for the first time, to non-invasively produce well-defined populations of individually programmed cells, eventually leading to substantial breakthroughs and numerous applications in the fields of molecular medicine and cellular nano-biotechnology. Although surface imprinting of cells will be realised via artificial nano-biotechnological devices, e.g. nanostructured stamps or beads, these tools are designed according to the natural principles of cellular signalling and differentiation. As nanocomponents are essential to the imprinting process, suitable techniques and principles to form nanoscaled macromolecular patterns on arbitrary surface geometries have to be developed. All components, ranging from the nanoscale of functional interfaces up to the macro level for cell handling, are to be developed as functional modules suitable for further application.

The project features multiple nano- and biotechnological challenges. To tackle these, will lead to breakthroughs in nanotechnological device development and, moreover, drastically advance our understanding of biological signals relevant to cellular programming. Once available, CellPROMs will facilitate the transition to a more knowledge-based and less resource-intensive society in Europe.

Call for proposal

FP6-2002-NMP-1
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Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27c
Muenchen
Germany

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Participants (26)

AMO GMBH - GESELLSCHAFT FUER ANGEWANDTE MIKRO- UND OPTOELEKTRONIK MBH
Germany
Address
Huyskensweg 25
Aachen

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
Address
Ecublens Vd
Lausanne

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EUROGENTEC SA
Belgium
Address
Liege Science Park, Rue Bois Saint Jean 14
Seraing

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EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Address
Science Park Saar, Stuhlsatzenhausweg 69
Saarbruecken

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EVOTEC TECHNOLOGIES GMBH
Germany
Address
Schnackenburgallee 114
Hamburg

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GEORG-SPEYER-HAUS - CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT
Germany
Address
Paul-ehrlich-strasse 42-44
Frankfurt Am-main

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GESELLSCHAFT ZUR FOERDERUNG DER ANALYTISCHEN WISSENSCHAFTEN E.V.
Germany
Address
Bunsen-kirchhoff Strasse 11
Dortmund

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GESIM - GESELLSCHAFT FUER SILIZIUM-MIKROSYSTEME MBH
Germany
Address
Bautzner Landstrasse 45
Grosserkmannsdorf

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INSTITUT FUER NEUE MATERIALIEN GMBH
Germany
Address
Im Stadtwald Gebauede 43
Saarbruecken

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INSTITUT PASTEUR
France
Address
Rue De Docteur Roux 25-28
Paris

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INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
Address
Av. Da Republica - Quinta Do Marquês
Oeiras

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KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
Address
Valhallavaegen 79
Stockholm

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LEISTER PROCESS TECHNOLOGIES
Switzerland
Address
Riedstrasse
Sarnen

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MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
Germany
Address
Hofgartenstrasse 8
Muenchen

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SILEX MICROSYSTEMS AB
Sweden
Address
Bruttovaegen 1
Jarfalla

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SURFACE IMAGING SYSTEMS (S.I.S.) RASTERSONDEN- UND SENSORMESSTECHNIK GMBH
Germany
Address
Kaiserstrasse 100
Herzogenrath

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SYSMELEC SA
Switzerland
Address
Route De Berne 5
Gals

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TECHNISCHE UNIVERSITAET KAISERSLAUTERN
Germany
Address
Gottlieb-daimler-strasse
Kaiserslautern

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TEL AVIV UNIVERSITY
Israel
Address
Ramat Aviv
Tel Aviv

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TP21 GMBH
Germany
Address
Tuerkenstrasse 4
Saarbruecken

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UNIVERSITA DEGLI STUDI DI PAVIA
Italy
Address
Strada Nuova, 65
Pavia

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UNIVERSITAET DES SAARLANDES
Germany
Address
Im Stadtwald 45
Saarbruecken

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UNIVERSITAET WIEN
Austria
Address
Dr. Karl Lueger-ring 1
Wien

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UNIVERSITAS VILNENSIS
Lithuania
Address
Universiteto 3
Vilnius

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UNIVERSITAT DE BARCELONA
Spain
Address
Gran Via De Les Corts Catalanes 585
Barcelona

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UNIVERZA V LJUBLJANI
Slovenia
Address
Kongresni Trg 12
Ljubljana

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