Objetivo The goal of this research project is to study and develop novel synergistic technologies for the next generation of high performance biochips, for future applications e.g. in accelerated drug discovery, diagnostics and personalized medicine. One of the key technologies relies on a predictable self-organization of fluids, using both static and dynamic formats will be utilized. The formats will be combined to overcome current bottlenecks in the automation of high throughput assays, and will also be used for the development of a new concept for automated chip replication. Other complementary technologies deal with surface-expanded high-density bio probe arrays, including the use of novel polymers. Also, novel magnetic bio Nan wires, controlled by an external magnetic field onto a platform of magnetic handouts, will be explored. It is anticipated that the use of these technologies will provide unique possibilities to increase legend density, as well as enhanced kinetics, resulting in enhanced sensitivity and faster assay performance. A third technology based on externally applied surface acoustic waves will be incorporated into the platform, yielding extremely efficient agitation of Nan droplets. Finally, a Nan electrochemical detection system will be developed. The technologies will be combined to yield an optimised Nan array chip, including the novel fluid agitation and bio-Nan wires principles. The optimised structure will be tested using standard bioassays, and the results obtained will be compared with performance data, obtained from similar experiments with state of the art biochips. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverysocial sciencessociologyindustrial relationsautomationnatural scienceschemical sciencespolymer sciencesmedical and health scienceshealth sciencespersonalized medicineengineering and technologynanotechnologynano-materials Palabras clave Nanotechnology biochip magnetic particles nanofluids nanopillars nanowires replication Programa(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Tema(s) NMP-2002-3.4.1.1-2 - Self-organisation and self-assembling NMP-2002-3.4.1.2-1 - Interfaces between biological and non biological entities Convocatoria de propuestas FP6-2002-NMP-1 Consulte otros proyectos de esta convocatoria Régimen de financiación STREP - Specific Targeted Research Project Coordinador KUNGLIGA TEKNISKA HOEGSKOLAN Aportación de la UE Sin datos Dirección Valhallavaegen, 79 10044 STOCKHOLM Suecia Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo INSTITUT CURIE Francia Aportación de la UE Sin datos Dirección 26, rue d'Ulm PARIS Ver en el mapa Coste total Sin datos NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN Alemania Aportación de la UE Sin datos Dirección Markwiesenstrasse 55 REUTLINGEN Ver en el mapa Coste total Sin datos ECOLE NORMALE SUPERIEURE Francia Aportación de la UE Sin datos Dirección 45 Rue D'Ulm PARIS Ver en el mapa Coste total Sin datos DIAGNOSWISS SA Suiza Aportación de la UE Sin datos Dirección Route de l'Ile-au-Bois 2, C/o Cimo S.A., Case Postale MONTHEY Ver en el mapa Coste total Sin datos ADVALYTIX AG Alemania Aportación de la UE Sin datos Dirección Eugen-Saenger-Strasse 53 BRUNNTHAL Ver en el mapa Coste total Sin datos
