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Development of a bioartificial pancreas for type I diabetes therapy

Objective

Four to five million people in Europe and about 80 million worldwide suffer from type 1 diabetes (insulin-dependent), characterized by a deficiency in insulin secretion resulting in hyperglycaemia responsible for debilitating long-term complications (coronary diseases, acquired blindness, chronic renal failures). Recently developed immunosuppressive protocols improved the success of humanallogenic pancreatic islets transplantation. However, such transplantation has severe limitations: the number of available donors and the potential toxicity of the immunosuppressive treatments. To avoidimmunosupression, islets could be encapsulated to protect them from the attack of the immune system and thus from rejection.
This project intends to develop, improve and validate an efficient reliablebioartificial pancreas for human application. To achieve this ambitious goal, various disciplines reintegrated in a true task force of basic and clinical researchers with leading expertise in experimental diabetes and advanced modern material technologies to develop an effective approach for the treatment of type 1 diabetes. The proposed approach takes into account the far-reaching advances in the modernnanosize technology, which are of utmost importance for the success of this challenge. To canny out the project to a successful achievement, the consortium gathers a multidisciplinary group of leading European scientists with complementary competencies, spending from biomaterials to tissue engineering, and high-tech Sees. This transactional approach provides convincing solutions to bypass the limitations of traditional treatments of this disease. That proposal fits perfectly within the scope of Priority Nan technologies and Nan sciences, 3.4.1, in particular Biotechnologies-biotechnologies, 3.4.1.2.Furthermore, the proposal addressed also the 3.4.1.5, Application in areas such as health and medical systems, chemistry, energy, optics, food and environment.

Call for proposal

FP6-2002-NMP-1
See other projects for this call

Funding Scheme

STREP - Specific Targeted Research Project
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Coordinator

CENTRE EUROPEEN D'ETUDES DU DIABETE
Address
Hopitaux Universitaires De Strasbourg, Boulevard Rene Leriche
Strasbourg
France

Participants (13)

ASSOCIATION POUR LES TRANSFERTS DE TECHNOLOGIE DU MANS
France
Address
20 Rue De Thales De Milet
Le Mans
BAYERISCHE JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG
Germany
Address
Sanderring 2
Wuerzburg
CELL CONCEPTS GMBH
Germany
Address
Mundenhofer Weg 28
Umkirch
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel Ange 3
Paris
EMPRESA DE CONSULTORIA EM BIOTECNOLOGIA LDA
Portugal
Address
Av. Da Republica E.a.n. Edificio Itqb/ibet - Laboratorio 4.11
Oeiras
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
France
Address
147 Rue De L'universite
Paris
ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI"
Italy
Address
Via Eritrea 62
Milano
ISTITUTO NAZIONALE PER LA FISICA DELLA MATERIA
Italy
Address
Corso Perrone 24
Genova
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Address
Carl-neuberg-strasse 1
Hannover
STATICE SANTE SA
France
Address
Zone Industrielle Des Tilleroyes, 9 Rue Thomas Edison
Besancon
UNIVERSITA DEGLI STUDI DI PISA
Italy
Address
Via Lungarno Pacinotti 43
Pisa
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
Address
1 Place De L'universite
Louvain-la-neuve
UNIVERSITE LIBRE DE BRUXELLES
Belgium
Address
Avenue Franklin Roosevelt 50
Bruxelles