Objective Four to five million people in Europe and about 80 million worldwide suffer from type 1 diabetes (insulin-dependent), characterized by a deficiency in insulin secretion resulting in hyperglycaemia responsible for debilitating long-term complications (coronary diseases, acquired blindness, chronic renal failures). Recently developed immunosuppressive protocols improved the success of humanallogenic pancreatic islets transplantation. However, such transplantation has severe limitations: the number of available donors and the potential toxicity of the immunosuppressive treatments. To avoidimmunosupression, islets could be encapsulated to protect them from the attack of the immune system and thus from rejection.This project intends to develop, improve and validate an efficient reliablebioartificial pancreas for human application. To achieve this ambitious goal, various disciplines reintegrated in a true task force of basic and clinical researchers with leading expertise in experimental diabetes and advanced modern material technologies to develop an effective approach for the treatment of type 1 diabetes. The proposed approach takes into account the far-reaching advances in the modernnanosize technology, which are of utmost importance for the success of this challenge. To canny out the project to a successful achievement, the consortium gathers a multidisciplinary group of leading European scientists with complementary competencies, spending from biomaterials to tissue engineering, and high-tech Sees. This transactional approach provides convincing solutions to bypass the limitations of traditional treatments of this disease. That proposal fits perfectly within the scope of Priority Nan technologies and Nan sciences, 3.4.1 in particular Biotechnologies-biotechnologies, 3.4.1.2.Furthermore the proposal addressed also the 3.4.1.5 Application in areas such as health and medical systems, chemistry, energy, optics, food and environment. Fields of science medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicinetransplantation Keywords Artificial Organs Biotechnology Cell & Tissue Engineering Diabetes Medical Device Molecular# Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2002-3.4.1.2-1 - Interfaces between biological and non biological entities NMP-2002-3.4.1.5-2 - Applications in the field of energy and chemistry, with focus on catalysis Call for proposal FP6-2002-NMP-1 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator CENTRE EUROPEEN D'ETUDES DU DIABETE EU contribution No data Address Hopitaux Universitaires de Strasbourg, Boulevard Rene Leriche STRASBOURG France See on map Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all ASSOCIATION POUR LES TRANSFERTS DE TECHNOLOGIE DU MANS France EU contribution No data Address 20 Rue de Thales de Milet LE MANS See on map Total cost No data BAYERISCHE JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG Germany EU contribution No data Address Sanderring 2 WUERZBURG See on map Total cost No data CELL CONCEPTS GMBH Germany EU contribution No data Address Mundenhofer Weg 28 UMKIRCH See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Michel Ange 3 PARIS See on map Total cost No data EMPRESA DE CONSULTORIA EM BIOTECNOLOGIA LDA Portugal EU contribution No data Address Av. da Republica E.A.N. Edificio ITQB/IBET - Laboratorio 4.11 OEIRAS See on map Total cost No data INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE France EU contribution No data Address 147 Rue de l'Universite PARIS See on map Total cost No data ISTITUTO DI RICERCHE FARMACOLOGICHE "MARIO NEGRI" Italy EU contribution No data Address Via Eritrea 62 MILANO See on map Total cost No data ISTITUTO NAZIONALE PER LA FISICA DELLA MATERIA Italy EU contribution No data Address Corso Perrone 24 GENOVA See on map Total cost No data MEDIZINISCHE HOCHSCHULE HANNOVER Germany EU contribution No data Address Carl-Neuberg-Strasse 1 HANNOVER See on map Total cost No data STATICE SANTE SA France EU contribution No data Address Zone Industrielle des Tilleroyes, 9 Rue Thomas Edison BESANCON See on map Total cost No data UNIVERSITA DEGLI STUDI DI PISA Italy EU contribution No data Address Via Lungarno Pacinotti 43 PISA See on map Total cost No data UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium EU contribution No data Address 1 Place de l'Universite LOUVAIN-LA-NEUVE See on map Total cost No data UNIVERSITE LIBRE DE BRUXELLES Belgium EU contribution No data Address Avenue Franklin Roosevelt 50 BRUXELLES See on map Total cost No data
