Objetivo Treatment of severe and fulminant form of viral hepatitis prevailing in the countries of Central Asia due to low hygienic standards especially in the country regions (HAV) and vulgar opiate drug addiction with tradition of needle-sharing (HBV and HCV) is a very challenging medical problem. The main objective of the project is to study the efficiency and potential of the introduction of new HSGD hemosorbents developed in Ukraine in the treatment of widespread severe and fulminant forms of viral hepatitis on the territory of Uzbekistan. This objective will be achieved through the introduction of new generation of carbonic mass-fractal pyropolymers HSGD, optimization of extra corporeal purification procedure, and studies of its clinical efficacy and mechanisms of action. In the course of this study, production of carbonic pyropolymers in single-used columns for the official registration and certification in agreement with national standards of Uzbekistan, primary expertise, medical and ethical approval of clinical tests will be done. The improvement of HSGD biocompatibility and adsorptive properties towards practically important protein-bound toxins, typical for hepatic insufficiency including unconjugated bilirubin, phenols, indoles, bile acids, free fatty acids and viral components via optimization of method of ex-tempore human serum albumin (HSA) coating carbonic surface will be performed. Results of testing of HSA-coated and uncoated HSGD in the model experiments with albumin-containing stock solutions of tightly protein-bound markers of hepatic insufficiency and viral components as well as their hemocompatibility and efficacy for purification of blood plasma, obtained from patients with severe and fulminant forms of viral hepatitis will be carried out. The common final conclusion about possibilities and prospects of direct removal of HCV and HBV viruses and its component from patients blood and blood plasma using extra corporeal technique of blood purification onto HSGD mass fractal carbonic adsorbents in single-used cartridges will be acquired. Realization of this project will give a major break-through on the way of successful extra corporeal treatment of complicated and fulminant forms of viral hepatitis in Uzbekistan. Programa(s) IC-INTAS - International Association for the promotion of cooperation with scientists from the independent states of the former Soviet Union (INTAS), 1993- Tema(s) Uzbekistan 2004 - INTAS Collaborative Call with Uzbekistan Convocatoria de propuestas Data not available Régimen de financiación Data not available Coordinador University of Brighton Aportación de la UE Sin datos Dirección Lewes Road BN2 4GJ Brighton Reino Unido Ver en el mapa Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Academy of Medical Sciences, 1st Tashkent State Medical Institute Uzbekistán Aportación de la UE Sin datos Dirección Musakhanova 103 700048 Tashkent Ver en el mapa Coste total Sin datos Academy of Medical Sciences, Republic Specialized Center of Surgery Uzbekistán Aportación de la UE Sin datos Dirección Farkhadskaya 10 700115 Tashkent Ver en el mapa Coste total Sin datos Academy of Sciences Experimental Pathology, Oncology and Radiobiology Ucrania Aportación de la UE Sin datos Dirección Vasilkovskaya 45 03022 Kiev Ver en el mapa Coste total Sin datos Danube University of Krems Austria Aportación de la UE Sin datos Dirección Dr Karl Dorrek Stra?e 30 3500 Krems Ver en el mapa Coste total Sin datos King's College London, Guy's, King's & St Thomas's School of Medicine Reino Unido Aportación de la UE Sin datos Dirección Bessemer Road SE5 9PJ London Ver en el mapa Coste total Sin datos
