Objectif The aim of this project is to develop a non-invasive diagnostic tool for medical applications, such as the early diagnosis of diseases, by real-time analysis of trace gas concentrations in human breath. Presently, early detection requires very expensive invasive tests, e.g. biopsy, endoscopy and x-rays that may be painful and potentially harmful. The challenge to modern medicine is to develop cost-effective and non-invasive tests for early diagnosis. We propose to develop and apply a novel type of laser-based analytical instrument, the optical nose, for rapid screening of human breath, in order to identify in real time the specific markers related to various diseases. We shall focus on chronic obstructive pulmonary diseases, lung cancer and colorectal cancer, as lead to get a "proof of concept". The consortium will perform research on the currently most promising trace gas analysis methods based on advanced mid-IR laser sources, optical parametric oscillators (OPOs), in combination with ultra-sensitive spectroscopic detection methods. By exploiting the latest solid-state laser and optical fibre technology, the capabilities of existing OPOs will be considerably extended and matching detection methods will be developed to retrieve and computer-analyse trace gas concentration data within only seconds. The laser-based analytical instrument will operate in the 2.5-10 mm wavelength range with maximum coverage of the molecular fingerprint region and a superior wavelength agility (tens of thousands of distinct wavelengths per second). This enables rapid and accurate medical examination of human breath, as required for building a database connecting the spectroscopic data of the breath analysis with medical evidence. Champ scientifique natural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicineoncologylung cancermedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesphysical sciencesopticsfibre opticsnatural sciencesphysical sciencesopticslaser physics Mots‑clés Non-invasive analytical tool cancer early diagnosis fiber laser medicine optical parametric oscillators real-time breath profiling trace gas detection Programme(s) FP6-POLICIES - Policy support: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Thème(s) NEST-2003-1 - Adventure activities Appel à propositions FP6-2003-NEST-A Voir d’autres projets de cet appel Régime de financement STREP - Specific Targeted Research Project Coordinateur STICHTING KATHOLIEKE UNIVERSITEIT Contribution de l’UE Aucune donnée Adresse Toernooiveld 1 NIJMEGEN Pays-Bas Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire EUROPEAN LABORATORY FOR NON-LINEAR SPECTROSCOPY Italie Contribution de l’UE Aucune donnée Adresse Via Nello Carrara, 1 FIRENZE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée LASER ZENTRUM HANNOVER E.V. Allemagne Contribution de l’UE Aucune donnée Adresse Hollerithallee 8 HANNOVER Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée SIFAM FIBRE OPTICS LIMITED Royaume-Uni Contribution de l’UE Aucune donnée Adresse Broomhill Way TORQUAY Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITAIR MEDISCH CENTRUM UTRECHT Pays-Bas Contribution de l’UE Aucune donnée Adresse Heidelberglaan 100 UTRECHT Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée UNIVERSITEIT TWENTE Pays-Bas Contribution de l’UE Aucune donnée Adresse Drienerlolaan 5 ENSCHEDE Voir sur la carte Liens Site web Opens in new window Coût total Aucune donnée